Since 2007-08, Samir Handanovič has made the most appearances in Serie A, with 559 appearances.

most games by a player after 2007

	NAME	M	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Samir Handanovič S. Handanovič	559	49,980	559	0	0.00	0	0	0
2	Andrea Consigli A. Consigli	510	45,538	510	0	0.00	0	0	0
3	Antonio Candreva A. Candreva	502	36,702	424	85	0.17	79	164	22
4	Fabio Quagliarella F. Quagliarella	483	33,107	377	166	0.34	34	200	32
5	Lorenzo De Silvestri L. De Silvestri	454	33,163	377	27	0.06	22	49	0
6	Leonardo Bonucci L. Bonucci	435	36,566	404	32	0.07	4	36	3
7	Francesco Acerbi F. Acerbi	415	35,502	394	24	0.06	9	33	1
8	Marek Hamšík M. Hamšík	408	31,477	375	100	0.25	64	164	7
9	Juan Cuadrado J. Cuadrado	405	27,812	302	44	0.11	63	107	2
10	Piotr Zieliński P. Zieliński	400	24,017	261	45	0.11	52	97	3
11	Giacomo Bonaventura G. Bonaventura	380	27,347	313	65	0.17	40	105	0
12	Goran Pandev G. Pandev	377	21,404	239	75	0.20	27	102	2
13	Giorgio Chiellini G. Chiellini	376	31,667	359	24	0.06	15	39	0
14	Radja Nainggolan R. Nainggolan	367	29,575	336	48	0.13	37	85	0
15	Paulo Dybala P. Dybala	359	24,349	282	130	0.36	67	197	33
16	Rodrigo Palacio R. Palacio	357	25,804	288	93	0.26	51	144	4
17	Ciro Immobile C. Immobile	354	26,952	310	201	0.57	49	250	52
18	Andrea Belotti A. Belotti	351	23,810	261	116	0.33	33	149	27	0	817	308	32	10,254	1,180	223
19	Marco Parolo M. Parolo	351	28,127	317	44	0.13	26	70	0
20	Stefano Sorrentino S. Sorrentino	351	31,518	351	0	0.00	0	0	0
21	Ştefan Radu Ş. Radu	350	29,125	340	5	0.01	11	16	0
22	Alessio Romagnoli A. Romagnoli	347	29,278	330	15	0.04	4	19	0
23	Antonio Mirante A. Mirante	346	30,549	343	0	0.00	1	1	0
24	Alessandro Matri A. Matri	345	18,559	198	92	0.27	14	106	6
25	Danilo	344	30,486	343	12	0.03	4	16	0