David James has made the most career appearances by a player 22 or older in the Premier League, with 572 appearances.

most games after turning 22 years old by a player

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	David James D. James	572	51,298	571	0	0.00	2	2	0
2	Gary Speed G. Speed	535	46,319	521	80	0.15	44	124	10
3	Mark Schwarzer M. Schwarzer	514	46,181	514	0	0.00	1	1	0
4	Gareth Barry G. Barry	512	42,872	488	47	0.09	57	104	18
5	Ryan Giggs R. Giggs	511	36,708	411	81	0.16	137	218	2
6	Frank Lampard F. Lampard	491	39,557	444	160	0.33	93	253	42
7	James Milner J. Milner	486	29,313	316	44	0.09	73	117	18
8	Sylvain Distin S. Distin	469	40,618	451	7	0.01	6	13	0
9	Ashley Young A. Young	452	34,112	380	45	0.10	68	113	5
10	Peter Crouch P. Crouch	451	27,499	298	105	0.23	56	161	1
11	Brad Friedel B. Friedel	450	40,428	450	1	0.00	0	1	0
12	Paul Scholes P. Scholes	449	33,544	379	91	0.20	51	142	1
13	Petr Čech P. Čech	443	39,495	442	0	0.00	2	2	0
14	Alan Shearer A. Shearer	441	38,197	427	260	0.59	64	324	56
15	Jussi Jääskeläinen J. Jääskeläinen	436	39,080	435	0	0.00	3	3	0
16	Jamie Carragher J. Carragher	431	37,011	414	1	0.00	12	13	0
17	Shay Given S. Given	429	38,236	429	0	0.00	2	2	0
18	John Terry J. Terry	428	37,140	420	39	0.09	11	50	0
19	Gareth Southgate G. Southgate	420	37,383	420	16	0.04	16	32	0
20	Teddy Sheringham T. Sheringham	418	31,963	350	146	0.35	76	222	21
21	Phil Neville P. Neville	416	33,197	373	8	0.02	20	28	0
22	John O'Shea J. O'Shea	406	30,556	342	13	0.03	13	26	0
23	Andy Cole A. Cole	404	30,725	340	179	0.44	72	251	1
24	Steven Gerrard S. Gerrard	402	33,911	381	110	0.27	76	186	31
25	Kevin Davies K. Davies	401	31,753	361	78	0.19	51	129	5