Donato Gama has made the most career appearances by a player 25 or older in LaLiga, with 466 appearances.

most games after turning 25 years old by a player

	NAME	M	MIN	START	G	G/M	A	G+A	PK
1	Donato Gama D. Gama	466	37,190	415	49	0.11			13
2	Francisco Buyo F. Buyo	456	40,979	456	0	0.00			0
3	Andoni Zubizarreta A. Zubizarreta	443	39,752	443	0	0.00			0
4	Joaquín	442	26,778	296	48	0.11	27	75	4
5	Aduriz	435	30,029	330	155	0.36	18	173	24
6	Raúl García R. García	421	25,349	281	96	0.23	26	122	19
7	Patxi Punal P. Punal	420	33,449	381	22	0.05	2	24	15
8	Dani Parejo D. Parejo	400	32,771	372	64	0.16	63	127	31
9	Iago Aspas I. Aspas	400	30,608	346	167	0.42	59	226	41
10	Luka Modrić L. Modrić	394	27,290	310	30	0.08	60	90	2
11	José Francisco Molina J. Francisco Molina	392	35,149	392	0	0.00			0
12	Miguel Ángel Fuentes M. Ángel Fuentes	390	32,274	354	5	0.01			0
13	Jon Andoni Larrañaga J. Andoni Larrañaga	390	34,157	377	11	0.03			0
14	Diego López D. López	388	34,682	387	0	0.00	0	0	0
15	Valeri Georgievich Karpin V. Georgievich Karpin	384	32,403	370	68	0.18			13
16	Manuel Enrique Jiménez M. Enrique Jiménez	383	34,170	380	7	0.02			0
17	Eusebio Sacristán E. Sacristán	371	23,763	258	18	0.05			0
18	José Ramón Esnaola J. Ramón Esnaola	371	33,292	370	0	0.00			0
19	Miroslav Đukić M. Đukić	368	31,833	355	11	0.03			2
20	Ivan Rakitić I. Rakitić	366	25,357	283	51	0.14	49	100	8
21	Pedro Manuel Munitis P. Manuel Munitis	364	24,921	275	29	0.08			0
22	Miquel Àngel Nadal M. Àngel Nadal	363	29,466	318	19	0.05			0
23	Ismael Urzaiz I. Urzaiz	362	25,084	279	114	0.31			7
24	Diego Rodríguez D. Rodríguez	361	31,835	359	9	0.02			0
25	Joaquín Alonso J. Alonso	361	31,847	359	59	0.16			18