Between the 1999-00 and 2008-09 seasons, Francesco Totti tallied the most goals in Serie A, with 142 goals.

most goals by a player 2000s

	NAME	G	M	MIN	START	G/M	PK
1	Francesco Totti F. Totti	142	272	23,265	268	0.52	40
2	Andriy Shevchenko A. Shevchenko	127	226	17,174	195	0.56	24
3	Alessandro Del Piero A. Del Piero	118	268	19,526	228	0.44	35
4	David Trezeguet D. Trezeguet	116	195	14,503	167	0.59	6
5	Christian Vieri C. Vieri	114	193	13,002	135	0.59	15
6	Alberto Gilardino A. Gilardino	113	281	18,973	207	0.40	9
7	Cristiano Lucarelli C. Lucarelli	104	236	19,116	218	0.44	20
8	Hernán Crespo H. Crespo	98	196	13,885	161	0.50	9
9	Filippo Inzaghi F. Inzaghi	94	226	15,537	173	0.42	3
10	Luca Toni L. Toni	91	177	14,999	171	0.51	6
11	Adrian Mutu A. Mutu	87	212	15,897	186	0.41	17
12	Vincenzo Montella V. Montella	87	205	12,709	140	0.42	8
13	Marco Di Vaio M. Di Vaio	86	198	13,209	142	0.43	8
14	Tommaso Rocchi T. Rocchi	85	238	18,875	213	0.36	7
15	Nicola Amoruso N. Amoruso	81	254	18,220	198	0.32	16
16	Zlatan Ibrahimovic Z. Ibrahimovic	80	158	12,418	142	0.51	11
17	Vincenzo Iaquinta V. Iaquinta	78	228	14,348	156	0.34	13
18	Adriano	77	175	12,702	141	0.44	7
19	Julio Cruz J. Cruz	76	218	14,305	161	0.35	8
20	Antonio Di Natale A. Di Natale	73	217	16,266	187	0.34	8
21	Cristiano Doni C. Doni	73	214	17,345	198	0.34	19
22	Kaká	70	193	15,493	174	0.36	19
23	Enrico Chiesa E. Chiesa	68	200	13,705	161	0.34	10
24	Antonio Cassano A. Cassano	67	223	15,506	172	0.30	4
25	David Di Michele D. Di Michele	60	213	15,849	179	0.28	7