Francesco Totti and Nils Gunnar Nordahl are tied for having the most career goals by a player 22 or older in Serie A, with 225 goals.

most goals by a player after turning 22 years old

	NAME	G	M	MIN	START	G/M	A	G+A	PK
1	Francesco Totti F. Totti	225	500	39,093	451	0.45	46	271	70
2	Nils Gunnar Nordahl N. Gunnar Nordahl	225	291	26,100	291	0.77			1
3	Antonio Di Natale A. Di Natale	209	445	33,917	389	0.47	27	236	33
4	Ciro Immobile C. Immobile	201	351	26,942	310	0.57	49	250	52
5	Silvio Piola S. Piola	201	380	34,030	380	0.53			23
6	Roberto Baggio R. Baggio	189	404	32,178	371	0.47			62
7	Giuseppe Signori G. Signori	188	344	27,754	323	0.55			44
8	Kurt Roland Hamrin K. Roland Hamrin	185	393	34,801	388	0.47			12
9	Gabriel Batistuta G. Batistuta	184	318	27,116	306	0.58			14
10	Fabio Quagliarella F. Quagliarella	182	551	37,901	432	0.33	34	216	32
11	José João Altafini J. João Altafini	169	393	33,188	364	0.43			15
12	Alessandro Del Piero A. Del Piero	168	403	27,921	322	0.42	5	173	49
13	Roberto Boninsegna R. Boninsegna	165	359	31,809	356	0.46			30
14	Luca Toni L. Toni	157	344	27,181	307	0.46	16	173	17
15	Zlatan Ibrahimovic Z. Ibrahimovic	156	283	21,772	249	0.55	29	185	30
16	Filippo Inzaghi F. Inzaghi	156	370	24,766	271	0.42	0	156	9
17	Luis Vinicio L. Vinicio	155	348	31,185	348	0.45			15
18	Alberto Gilardino A. Gilardino	153	400	30,671	344	0.38	13	166	12
19	Istvan Nyers I. Nyers	153	236	21,195	236	0.65			36
20	Giuseppe Savoldi G. Savoldi	151	338	30,099	337	0.45			42
21	Enrique Omar Sívori E. Omar Sívori	145	274	24,210	274	0.53			10
22	Carlo Reguzzoni C. Reguzzoni	144	371	33,300	371	0.39			18
23	Hernán Crespo H. Crespo	141	313	21,419	244	0.45	0	141	14
24	Vincenzo Montella V. Montella	141	288	19,713	220	0.49			21
25	Christian Vieri C. Vieri	141	257	17,802	189	0.55			17