Since 2019-20, Liverpool have the most wins by a club in the Premier League against Big Six opponents, with 30 wins.

	CLUB	W	M	D	L	G	GC	XG	XGA	SH	SOT	PASS-ATT	PASS	POSS%	FOUL	YC	RC
1	Liverpool	30	63	21	12	130	82			944	341	34,000	28,632	54.3	679	114	4
2	Man City	29	63	14	20	108	78			958	330	37,619	33,319	58.8	608	105	2
3	Arsenal	27	63	15	21	95	95			706	247	27,038	22,414	46.1	690	138	7
4	Brighton	26	76	14	36	109	132			947	325	34,999	29,256	48.2	838	149	2
5	Aston Villa	21	75	10	44	89	140			790	289	26,600	21,183	40.0	792	143	4
6	Wolves	19	74	9	46	71	133			761	256	29,726	23,970	42.2	820	138	4
7	Chelsea	19	63	18	26	77	96			810	270	32,789	27,983	52.3	677	135	3
8	Man United	19	64	19	26	78	110			716	272	26,552	21,467	43.0	711	162	5
9	Newcastle	18	74	12	44	84	144			757	245	24,849	19,299	37.1	767	153	4
10	Tottenham	16	62	11	35	87	114			661	258	27,337	22,658	45.6	709	134	6
11	West Ham	15	75	11	49	76	157			714	242	26,386	20,692	36.4	753	127	6
12	Everton	13	75	22	40	61	138			702	228	24,608	18,722	35.5	827	177	5
13	Crystal Palace	13	75	20	42	69	141			699	254	25,097	19,031	35.5	804	132	2
14	Brentford	12	52	12	28	62	86	68.47	90.23	537	208	17,476	12,963	36.9	455	85	0
15	Leicester	12	60	7	41	63	122			576	214	25,657	20,728	43.8	604	106	2
16	Bournemouth	11	50	8	31	50	109			554	185	16,921	12,993	37.4	553	106	2
17	Nottm Forest	10	39	7	22	32	72	38.47	69.27	373	110	11,628	8,770	32.8	420	91	2
18	Fulham	8	51	11	32	46	86			507	172	20,591	16,616	42.1	528	109	4
19	Southampton	8	60	17	35	62	143			584	229	22,529	17,555	39.9	649	103	8
20	Leeds	4	38	6	28	39	108			415	139	14,997	11,675	44.1	423	79	5
21	Sheffield Utd	4	36	5	27	31	80			275	98	11,215	8,148	31.0	391	71	1
22	Burnley	4	53	9	40	29	121			479	137	17,195	12,617	35.0	505	91	3
23	Watford	3	24	4	17	21	54			251	85	7,796	5,689	34.6	246	44	1
24	Ipswich	2	12	2	8	12	32	10.71	24.87	96	37	3,830	3,048	33.7	138	26	1
25	Sunderland	1	2	0	1	2	3	1.88	2.89	18	7	708	560	40.2	25	5	0