Since 2000-01, Marek Hamšík has made the most appearances by a Napoli player in Serie A, with 408 appearances.

most all-time serie a appearances by a player for napoli after 2000

	NAME	M	Rating	MIN	START	G	G/M	A	G+A	PK	FK	SH	SOT	WOOD	TCH	TCH-BOX	OFF
1	Marek Hamšík M. Hamšík	408		31,477	375	100	0.25	64	164	7
2	Lorenzo Insigne L. Insigne	337		23,962	278	96	0.28	75	171	27
3	Dries Mertens D. Mertens	295		17,052	182	113	0.38	56	169	11
4	Piotr Zieliński P. Zieliński	281		18,203	205	37	0.13	40	77	1	0	414	142	13	14,493	471	15
5	José Callejón J. Callejón	255		19,872	229	64	0.25	52	116	0
6	Kalidou Koulibaly K. Koulibaly	236		20,705	233	13	0.06	5	18	0	0	97	34	1	19,247	146	4
7	Christian Maggio C. Maggio	233		18,612	211	20	0.09	16	36	0
8	Giovanni Di Lorenzo G. Di Lorenzo	225		20,075	224	14	0.06	26	40	0	0	171	55	5	18,394	559	28
9	Matteo Politano M. Politano	199		11,499	140	28	0.14	25	53	4	0	311	84	13	7,423	469	13
10	Paolo Cannavaro P. Cannavaro	197		16,989	192	6	0.03	2	8	0
11	Walter Gargano W. Gargano	189		14,860	168	4	0.02	6	10	0
12	Albiol	180		15,731	174	6	0.03	6	12	0
13	Elseid Hysaj E. Hysaj	178		14,807	167	1	0.01	10	11	0	0	56	14	0	13,858	104	18
14	Mário Rui M. Rui	173		13,109	149	3	0.02	21	24	0	1	126	33	5	13,998	150	15
15	Stanislav Lobotka S. Lobotka	170		12,338	139	2	0.01	4	6	0	0	36	9	0	10,318	41	0
16	Alex Meret A. Meret	168		14,900	166	0	0.00	0	0	0	0	0	0	0	5,509	0	0
17	Faouzi Ghoulam F. Ghoulam	160		11,389	124	3	0.02	19	22	0
18	Allan	158		11,191	127	11	0.07	20	31	0	0	117	33	1	10,203	115	1
19	Ezequiel Lavezzi E. Lavezzi	156		12,826	144	38	0.24	16	54	1
20	Eljif Elmas E. Elmas	153		5,741	48	14	0.09	9	23	1	0	117	46	3	4,074	190	9
21	Amir Rrahmani A. Rrahmani	152		12,991	146	11	0.07	4	15	0	0	104	26	2	11,740	146	3
22	Morgan De Sanctis M. De Sanctis	147		13,230	147	0	0.00	0	0	0
23	André-Frank Zambo Anguissa A. Zambo Anguissa	141	7.04	11,570	131	13	0.09	13	26	0	0	166	45	6	9,279	316	8
24	Pepe Reina P. Reina	141		12,589	141	0	0.00	1	1	0
25	Jorginho	133		10,128	118	2	0.02	12	14	1