The Chicago Cubs have the highest run differential by a team this season, with a differential of 108 runs.

Interpreted as:

highest MLB run differential by a team this regular season

	TEAM	DIFF	SEASON	G	W%	W	L	AB	R	H	2B	3B	HR	RBI	BB	HBP	SO	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS
1	Cubs	108	2025	67	.612	41	26	2,335	374	603	123	15	94	366	245	17	530	84	15	2,625	1,038	232	6	22	8	30	.258	.330	.445	.775
2	Yankees	103	2025	65	.615	40	25	2,212	359	578	117	10	107	346	265	31	573	49	15	2,534	1,036	234	1	25	18	42	.261	.345	.468	.813
3	Tigers	94	2025	68	.647	44	24	2,305	330	581	105	13	77	316	219	27	604	24	6	2,572	943	195	4	17	6	40	.252	.322	.409	.731
4	Mets	89	2025	67	.642	43	24	2,242	310	558	113	13	84	301	244	43	517	55	8	2,556	949	210	3	24	14	58	.249	.331	.423	.754
5	Dodgers	65	2025	68	.588	40	28	2,338	376	620	117	11	103	360	256	23	565	42	12	2,644	1,068	231	3	24	15	52	.265	.340	.457	.797
6	Rays	48	2025	67	.537	36	31	2,238	298	549	106	3	70	283	203	19	565	95	17	2,484	871	179	4	20	3	43	.245	.311	.389	.700
7	Giants	46	2025	67	.582	39	28	2,196	277	503	98	10	63	263	231	23	568	42	14	2,480	810	171	11	19	5	42	.229	.307	.369	.675
8	Reds	42	2025	68	.515	35	33	2,280	309	561	114	7	73	297	238	21	601	59	21	2,560	908	194	6	15	7	40	.246	.321	.398	.719
9	Padres	27	2025	66	.576	38	28	2,201	277	547	95	10	57	255	206	17	467	52	13	2,460	833	162	17	19	6	41	.249	.315	.378	.694
10	Cardinals	26	2025	67	.537	36	31	2,278	314	588	120	4	62	299	215	32	517	37	13	2,553	902	186	8	20	10	50	.258	.328	.396	.724
11	Twins	25	2025	66	.530	35	31	2,220	280	540	105	7	68	268	197	42	540	33	12	2,475	863	180	1	15	4	44	.243	.315	.389	.704
12	Astros	21	2025	66	.545	36	30	2,195	263	551	88	6	65	251	188	29	502	39	13	2,438	846	159	8	18	6	55	.251	.316	.385	.701
13	Brewers	20	2025	68	.529	36	32	2,261	297	532	91	5	61	274	240	28	558	86	20	2,560	816	157	15	16	8	32	.235	.314	.361	.675
14	Red Sox	17	2025	69	.478	33	36	2,411	341	614	133	9	84	327	241	32	642	60	14	2,703	1,017	226	5	14	14	35	.255	.329	.422	.751
15	Rangers	14	2025	67	.478	32	35	2,178	237	489	81	6	68	231	172	22	547	60	16	2,392	786	155	3	17	4	33	.225	.286	.361	.647
16	Phillies	12	2025	67	.567	38	29	2,283	305	578	102	9	69	289	235	24	526	60	12	2,564	905	180	7	15	8	42	.253	.327	.396	.724
17	Braves	6	2025	66	.424	28	38	2,241	267	545	94	6	71	257	226	22	568	36	12	2,508	864	171	7	12	7	40	.243	.317	.386	.703
18	Blue Jays	1	2025	67	.552	37	30	2,265	291	579	118	3	69	280	222	22	456	37	10	2,543	910	190	14	20	12	51	.256	.325	.402	.727
19	Diamondbacks	-7	2025	67	.493	33	34	2,272	341	578	125	14	96	334	250	30	512	53	15	2,588	1,019	235	11	25	9	49	.254	.333	.449	.781
20	Mariners	-11	2025	66	.500	33	33	2,259	289	545	82	4	86	280	237	33	594	65	18	2,552	893	172	10	13	5	40	.241	.321	.395	.716
21	Royals	-17	2025	67	.507	34	33	2,259	228	571	110	12	45	225	158	22	461	53	23	2,476	840	167	15	22	10	35	.253	.305	.372	.677
22	Guardians	-23	2025	66	.515	34	32	2,150	254	499	90	6	67	240	211	25	535	53	15	2,419	802	163	9	24	10	40	.232	.305	.373	.678
23	White Sox	-49	2025	67	.343	23	44	2,175	237	482	101	3	53	227	227	13	564	48	14	2,443	748	157	10	18	2	38	.222	.297	.344	.641
24	Angels	-51	2025	66	.485	32	34	2,192	279	495	92	7	95	269	167	30	637	31	12	2,411	886	194	6	16	7	38	.226	.288	.404	.692
25	Nationals	-52	2025	66	.455	30	36	2,184	279	522	110	10	65	266	184	34	507	57	23	2,426	847	185	10	14	2	40	.239	.306	.388	.694