Walter Johnson has pitched the most career complete games by a pitcher against a team, with 81 complete games against the White Sox.

Interpreted as:

most regular-season complete games by a player against one team

	NAME	CG	OPP	G	W	L	W%	GS	ERA	SO	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Walter Johnson W. Johnson	81	White Sox	125	63	39	.618	99	1.47	540	14	10	898.1	662		259	13	197	26	25			25	5.41	1.97	2.74	0.13		5.6	0.96	.238	2.59	6.63
2	Walter Johnson W. Johnson	79	Tigers	124	66	42	.611	105	1.88	521	12	5	920.0	798		346	11	276	32	19			25	5.10	2.70	1.89	0.11		7.5	1.17	.277	3.38	7.81
3	Walter Johnson W. Johnson	78	Yankees	108	61	38	.616	94	1.61	521	21	3	846.1	687		261	23	209	30	14			31	5.54	2.22	2.49	0.24		6.2	1.06	.256	2.78	7.31
4	Walter Johnson W. Johnson	75	Red Sox	112	53	43	.552	91	1.62	488	15	6	815.0	670		233	6	180	31	20			12	5.39	1.99	2.71	0.07		5.6	1.04	.262	2.57	7.40
5	Eddie Plank E. Plank	75	Tigers	106	60	31	.659	92	1.47	379	11	4	788.0	761		293	7	185	25	14			15	4.33	2.11	2.05	0.08		6.1	1.20	.307	3.35	8.69
6	Christy Mathewson C. Mathewson	75	Cubs	96	46	39	.541	87	0.89	355	14	5	749.1	654		283	18	113	4	8			17	4.26	1.36	3.14	0.22		3.8	1.02	.257	3.40	7.85
7	Grover Alexander G. Alexander	74	Reds	108	70	24	.745	96	2.04	326	20	4	847.0	736		246	10	152	13	12			6	3.46	1.62	2.14	0.11		4.6	1.05	.257	2.61	7.82
8	Walter Johnson W. Johnson	74	Athletics	112	59	39	.602	93	1.81	516	23	4	826.0	715		277	22	185	26	17			20	5.62	2.02	2.79	0.24		5.5	1.09	.266	3.02	7.79
9	Walter Johnson W. Johnson	73	Browns	112	56	37	.602	91	1.61	481	13	3	801.2	658		253	12	179	33	18			20	5.40	2.01	2.69	0.13		5.6	1.04	.260	2.84	7.39
10	Walter Johnson W. Johnson	71	Indians	109	59	41	.590	93	1.89	460	12	3	809.1	727		273	10	148	30	15			22	5.12	1.65	3.11	0.11		4.5	1.08	.275	3.04	8.08
11	Christy Mathewson C. Mathewson	69	Reds	95	65	19	.774	83	0.89	354	12	5	726.1	633		234	14	121	12	11			12	4.39	1.50	2.93	0.17		4.2	1.04	.263	2.90	7.84
12	Warren Spahn W. Spahn	67	Giants	119	56	43	.566	108	3.24	416	6	3	861.1	788	310	334	100	241	8	9		3,531	11	4.35	2.52	1.73	1.04	11.8	6.8	1.19	.249	3.49	8.23
13	Warren Spahn W. Spahn	66	Cardinals	125	64	41	.610	115	3.00	376	11	3	919.1	846	306	348	63	247	8	9		3,787	20	3.68	2.42	1.52	0.62	9.9	6.5	1.19	.253	3.41	8.28
14	Grover Alexander G. Alexander	66	Braves	105	57	28	.671	83	2.06	318	11	7	755.2	692		246	22	115	8	18		3,039	5	3.79	1.37	2.77	0.26	10.5	3.8	1.07	.260	2.93	8.24
15	Eddie Plank E. Plank	65	Red Sox	94	49	31	.613	82	1.25	339	8	2	691.0	596		230	10	154	30	11			15	4.42	2.01	2.20	0.13		5.8	1.09	.277	3.00	7.76
16	Grover Alexander G. Alexander	63	Robins	95	56	23	.709	81	2.02	308	16	6	723.0	654		233	13	122	6	13			8	3.83	1.52	2.52	0.16		4.2	1.07	.260	2.90	8.14
17	Christy Mathewson C. Mathewson	63	Pirates	107	54	38	.587	89	1.04	378	8	6	770.0	712		296	17	125	11	17			22	4.42	1.46	3.02	0.20		4.1	1.09	.277	3.46	8.32
18	Christy Mathewson C. Mathewson	63	Braves	90	55	24	.696	78	1.19	410	14	3	687.0	598		209	9	133	7	9			16	5.37	1.74	3.08	0.12		4.9	1.06	.270	2.74	7.83
19	Warren Spahn W. Spahn	59	Reds	113	62	29	.681	95	2.94	373	9	4	773.2	715	253	284	68	206	8	14	14	3,183	11	4.34	2.40	1.81	0.79	11.7	6.5	1.19	.256	3.30	8.32
20	Lefty Grove L. Grove	59	Tigers	102	60	19	.759	79	3.05	390	7	5	702.2	651	238	275	37	212	7	14		2,936	10	5.00	2.72	1.84	0.47	13.3	7.2	1.23	.268	3.52	8.34
21	Eddie Plank E. Plank	59	White Sox	92	41	33	.554	81	1.22	313	8	3	643.0	568		249	1	183	32	8			13	4.38	2.56	1.71	0.01		7.1	1.17	.279	3.49	7.95
22	Ted Lyons T. Lyons	58	Red Sox	80	39	28	.582	68	2.96	152	6	3	603.0	586	198	234	20	141	2	10		2,500	9	2.27	2.10	1.08	0.30	6.1	5.6	1.21	.259	3.49	8.75
23	Ted Lyons T. Lyons	57	Indians	89	51	26	.662	70	2.86	132	3	2	632.0	644	201	249	22	148	7	15		2,635	7	1.88	2.11	0.89	0.31	5.0	5.6	1.25	.267	3.55	9.17
24	George Mullin G. Mullin	57	Naps	72	29	32	.475	67	0.91	229	8	0	553.0	552		239	1	145	17	4			13	3.73	2.36	1.58	0.02		6.7	1.26	.312	3.89	8.98
25	Christy Mathewson C. Mathewson	57	Phillies	82	52	24	.684	77	0.84	334	9	0	630.1	572		212	12	127	10	5			16	4.77	1.81	2.63	0.17		5.1	1.11	.281	3.03	8.17