Charlie Root has appeared in the most career games for the Cubs, with 605 games.

Interpreted as:

most regular-season games as a cubs pitcher

	NAME	G	W	L	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Charlie Root C. Root	605	201	156	.563	339	3.55	1,432	177	21	42	3137.1	3,184	1,236	1,422	185	871	73	171		13,266	21	4.11	2.50	1.64	0.53	10.8	6.6	1.29	.280	4.08	90	3.78	94	9.13	85.7
2	Carlos Marmol C. Marmol	483	23	32	.418	13	3.50	703	0	0	117	542.1	355	211	223	45	366	49	245	18	2,359	30	11.67	6.07	1.92	0.75	29.8	15.5	1.33	.259	3.70	82	3.89	92	5.89	20.5
3	Lee Smith L. Smith	458	40	51	.440	6	2.92	644	0	0	180	681.1	591	221	240	38	264	6	342	61	2,828	34	8.51	3.49	2.44	0.50	22.8	9.3	1.25	.295	3.17	75	2.76	72	7.81	81.4
4	Don Elston D. Elston	449	49	54	.476	15	3.70	518	2	0	64	754.2	701	310	354	80	327	25	239	63	3,228	13	6.18	3.90	1.58	0.95	16.0	10.1	1.36	.273	4.22	95	3.93	103	8.36	-8.9
5	Guy Bush G. Bush	428	152	101	.601	252	3.81	712	127	14	27	2201.2	2,354	933	1,101	121	734	36	110		9,506	44	2.91	3.00	0.97	0.49	7.5	7.7	1.40	.283	4.50	93	4.18	102	9.62	-24.3
6	Pedro Strop P. Strop	413	22	24	.478	0	2.88	428	0	0	29	375.0	246	120	131	26	149	29	95	15	1,522	36	10.27	3.58	2.87	0.62	28.1	9.8	1.05	.247	3.14	71	3.18	79	5.90	35.2
7	Fergie Jenkins F. Jenkins	401	167	132	.559	347	3.20	2,038	154	29	6	2673.2	2,402	952	1,061	271	600	52	25	77	10,898	37	6.86	2.02	3.40	0.91	18.7	5.5	1.12	.268	3.57	84	3.06	83	8.09	182
8	Ryan Dempster R. Dempster	374	67	66	.504	154	3.74	1,070	3	1	87	1182.2	1,095	491	545	111	464	39	183	25	5,032	42	8.14	3.53	2.31	0.84	21.3	9.2	1.32	.294	4.15	88	3.77	90	8.33	55.7
9	William Hutchinson W. Hutchinson	368	180	158	.533	339	3.56	1,225	317	21	4	3022.1	3,055	1,196	1,861	99	1,109	84	28		13,196	120	3.65	3.30	1.10	0.29	9.3	8.4	1.38	.277	5.54	86	3.74	89	9.10	161
10	James Russell J. Russell	365	10	18	.357	5	4.03	223	0	0	4	306.0	310	137	161	41	91	9	62	21	1,307	6	6.56	2.68	2.45	1.21	17.1	7.0	1.31	.285	4.74	103	4.34	112	9.12	-15.5
11	Bill Lee B. Lee	364	139	123	.531	297	3.51	874	153	25	9	2271.1	2,317	885	1,013	111	704	19	37		9,631	45	3.46	2.79	1.24	0.44	9.1	7.3	1.33	.278	4.01	93	3.74	95	9.18	44.5
12	Rick Reuschel R. Reuschel	358	135	127	.515	343	3.50	1,367	65	17	3	2290.0	2,365	891	1,007	140	640	59	9	80	9,679	66	5.37	2.52	2.14	0.55	14.1	6.6	1.31	.298	3.96	89	3.15	82	9.29	171.2
13	Mordecai Brown M. Brown	346	188	86	.686	241	1.80	1,043	206	48	39	2329.0	1,879	465	679	19	445	44	98		8,967	41	4.03	1.72	2.34	0.07	11.6	5.0	1.00	.251	2.62	64	2.21	78	7.26	159.6
14	Kyle Farnsworth K. Farnsworth	343	22	37	.373	26	4.78	467	1	1	4	478.2	468	254	281	75	224	11	88	20	2,112	20	8.78	4.21	2.08	1.41	22.1	10.6	1.45	.294	5.28	109	4.62	102	8.80	-5.9
15	Kerry Wood K. Wood	341	80	68	.541	178	3.67	1,470	11	5	35	1279.0	1,000	521	556	137	609	93	69	18	5,421	54	10.34	4.29	2.41	0.96	27.1	11.2	1.26	.277	3.91	86	3.79	87	7.04	82.4
16	Bob Rush B. Rush	339	110	140	.440	292	3.71	1,076	112	13	7	2132.2	2,043	878	1,011	152	725	32	24	18	9,058	48	4.54	3.06	1.48	0.64	11.9	8.0	1.30	.267	4.27	92	3.45	85	8.62	140.5
17	Willie Hernandez W. Hernandez	323	26	28	.481	11	3.81	329	0	0	20	465.1	455	197	217	36	185	9	113	46	1,987	22	6.36	3.58	1.78	0.70	16.6	9.3	1.38	.293	4.20	95	3.55	92	8.80	17.6
18	Carlos Zambrano C. Zambrano	319	125	81	.607	282	3.60	1,542	9	4	0	1826.2	1,586	731	804	152	823	92	6	40	7,798	57	7.60	4.05	1.87	0.75	19.8	10.6	1.32	.276	3.96	83	3.97	92	7.81	75.9
19	Hippo Vaughn H. Vaughn	305	151	105	.590	270	2.33	1,138	177	35	4	2216.1	1,971	575	789	35	621	63	31		9,097	41	4.62	2.52	1.83	0.14	12.5	6.8	1.17	.267	3.20	79	2.56	86	8.00	96.3
20	Greg Maddux G. Maddux	302	133	112	.543	298	3.61	1,305	47	14	0	2016.0	1,962	808	908	160	547	60	3	81	8,416	38	5.83	2.44	2.39	0.71	15.5	6.5	1.24	.284	4.05	89	3.51	88	8.76	106
21	Bruce Sutter B. Sutter	300	32	30	.516	0	2.39	494	0	0	133	493.0	371	131	156	27	149	3	222	35	1,983	28	9.02	2.72	3.32	0.49	24.9	7.5	1.05	.263	2.85	60	2.31	60	6.77	82.2
22	Hector Rondon H. Rondon	296	18	13	.581	0	3.22	303	0	0	77	296.1	251	106	119	30	83	9	154	7	1,215	15	9.20	2.52	3.65	0.91	24.9	6.8	1.13	.280	3.61	81	3.32	84	7.62	20.7
23	Sean Marshall S. Marshall	292	32	40	.444	59	3.96	439	1	0	7	530.0	514	233	254	56	191	17	50	23	2,275	16	7.45	3.24	2.30	0.95	19.3	8.4	1.33	.291	4.31	89	4.01	91	8.73	18.8
24	Claude Passeau C. Passeau	292	124	94	.569	234	2.96	754	143	22	15	1914.2	1,919	629	751	73	474	21	44		8,063	17	3.54	2.23	1.59	0.34	9.4	5.9	1.25	.274	3.53	83	3.09	86	9.02	111
25	Ed Reulbach E. Reulbach	281	136	65	.677	216	2.24	799	149	31	9	1864.2	1,459	464	606	21	650	85	54		7,405	29	3.86	3.14	1.23	0.10	10.8	8.8	1.13	.246	2.92	79	2.87	99	7.04	0