Between the 2010 and 2019 seasons, Rick Porcello lost the most games, with 109 games.

Interpreted as:

most regular-season losses by a pitcher in the 2010s

	NAME	L	W	L%	G	W%	GS	ERA	SO	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Rick Porcello R. Porcello	109	135	.447	312	.553	308	4.40	1,418	10	3	0	1866.2	2,020	913	1,000	232	422	79	2	17	7,931	63	6.84	2.03	3.36	1.12	17.9	5.3	1.31	.309	4.82	103	4.02	97	9.74	25.4
2	James Shields J. Shields	103	102	.502	289	.498	287	4.02	1,619	18	7	0	1841.2	1,791	822	893	262	580	69	1	16	7,772	80	7.91	2.83	2.79	1.28	20.8	7.5	1.29	.292	4.36	101	4.24	105	8.75	-46.9
3	Jeff Samardzija J. Samardzija	101	78	.564	314	.436	235	4.05	1,397	9	4	0	1566.1	1,464	705	758	191	457	56	18	22	6,529	56	8.03	2.63	3.06	1.10	21.4	7.0	1.23	.287	4.36	102	3.90	99	8.41	6.4
4	Ian Kennedy I. Kennedy	99	96	.508	340	.492	277	4.03	1,590	2	1	30	1707.2	1,605	764	819	240	559	76	51	21	7,219	73	8.38	2.95	2.84	1.26	22.0	7.7	1.27	.287	4.32	100	4.18	105	8.46	-43.4
5	Mike Leake M. Leake	98	105	.483	301	.517	296	4.05	1,231	6	2	0	1829.0	1,940	824	905	238	403	68	2	29	7,693	33	6.06	1.98	3.05	1.17	16.0	5.2	1.28	.296	4.45	101	4.23	104	9.55	-35.5
6	Felix Hernandez F. Hernandez	95	111	.461	281	.539	280	3.40	1,714	18	8	0	1824.2	1,624	690	772	184	518	78	0	3	7,498	110	8.45	2.55	3.31	0.91	22.9	6.9	1.17	.288	3.81	87	3.51	87	8.01	100.9
7	Edwin Jackson E. Jackson	94	69	.577	273	.423	208	4.83	1,036	3	2	1	1290.0	1,379	693	760	167	480	25	22	30	5,620	80	7.23	3.35	2.16	1.17	18.4	8.5	1.44	.310	5.30	120	4.34	108	9.62	-48.8
8	Madison Bumgarner M. Bumgarner	92	119	.436	285	.564	285	3.14	1,784	15	6	0	1836.0	1,614	640	701	190	425	62	0	33	7,467	25	8.75	2.08	4.20	0.93	23.9	5.7	1.11	.284	3.44	83	3.31	87	7.91	97.9
9	Jon Lester J. Lester	92	148	.383	320	.617	320	3.54	1,868	11	2	0	1979.2	1,847	778	862	207	616	65	0	6	8,236	46	8.49	2.80	3.03	0.94	22.7	7.5	1.24	.299	3.92	85	3.61	89	8.40	93.3
10	Francisco Liriano F. Liriano	92	88	.511	342	.489	242	4.15	1,449	3	1	0	1456.1	1,320	672	732	143	680	54	13	14	6,277	83	8.95	4.20	2.13	0.88	23.1	10.8	1.37	.298	4.52	103	3.90	97	8.16	18.2
11	Jason Hammel J. Hammel	91	79	.535	270	.465	240	4.47	1,155	1	1	2	1426.1	1,472	708	752	185	429	57	18	19	6,117	60	7.29	2.71	2.69	1.17	18.9	7.0	1.33	.300	4.75	106	4.19	103	9.29	-15.1
12	Anibal Sanchez A. Sanchez	91	90	.503	289	.497	267	4.00	1,476	7	6	0	1613.1	1,564	717	783	185	497	40	9	31	6,826	52	8.23	2.77	2.97	1.03	21.6	7.3	1.28	.298	4.37	98	3.77	92	8.72	51.9
13	R.A. Dickey	90	98	.479	256	.521	252	3.66	1,206	14	5	0	1631.0	1,514	663	732	195	486	73	2	13	6,800	63	6.65	2.68	2.48	1.08	17.7	7.1	1.23	.273	4.04	91	4.20	105	8.35	-37.4
14	Ubaldo Jimenez U. Jimenez	89	83	.517	245	.483	232	4.53	1,279	7	3	1	1363.2	1,317	687	734	151	620	52	4	17	5,928	66	8.44	4.09	2.06	1.00	21.6	10.5	1.42	.305	4.84	109	4.13	99	8.69	5.3
15	Doug Fister D. Fister	88	80	.524	231	.476	216	3.70	934	8	2	1	1361.1	1,393	560	626	129	317	70	5	14	5,720	38	6.17	2.10	2.95	0.85	16.3	5.5	1.26	.296	4.14	92	3.80	94	9.21	33.9
16	Gio Gonzalez G. Gonzalez	88	123	.417	302	.583	300	3.49	1,683	4	2	0	1768.2	1,559	686	736	142	715	44	0	18	7,471	54	8.56	3.64	2.35	0.72	22.5	9.6	1.29	.290	3.75	87	3.53	88	7.93	92.7
17	Ricky Nolasco R. Nolasco	88	74	.543	225	.457	223	4.62	1,022	9	5	0	1329.0	1,482	682	722	165	324	37	1	25	5,694	41	6.92	2.19	3.15	1.12	17.9	5.7	1.36	.318	4.89	116	3.98	101	10.04	-5
18	Andrew Cashner A. Cashner	87	57	.604	300	.396	188	4.10	901	3	3	1	1196.0	1,180	545	616	130	442	39	20	20	5,109	43	6.78	3.33	2.04	0.98	17.6	8.7	1.36	.292	4.64	101	4.24	103	8.88	-18
19	Cole Hamels C. Hamels	87	115	.431	306	.569	305	3.33	1,872	11	3	0	1958.0	1,742	724	778	214	579	88	0	24	8,072	46	8.60	2.66	3.23	0.98	23.2	7.2	1.19	.287	3.58	81	3.64	89	8.01	97.2
20	Bud Norris B. Norris	87	61	.588	344	.412	178	4.45	1,099	0	0	47	1165.2	1,161	576	625	147	460	53	87	24	5,055	47	8.49	3.55	2.39	1.13	21.7	9.1	1.39	.308	4.83	112	4.16	104	8.96	-20.8
21	Jhoulys Chacin J. Chacin	86	77	.528	246	.472	225	4.03	1,051	3	1	0	1308.0	1,215	585	636	139	523	54	7	23	5,586	46	7.23	3.60	2.01	0.96	18.8	9.4	1.33	.282	4.38	94	4.20	101	8.36	-5.4
22	Justin Verlander J. Verlander	86	160	.350	321	.650	321	3.10	2,260	20	6	0	2142.0	1,738	737	797	228	568	52	0	10	8,635	50	9.50	2.39	3.98	0.96	26.2	6.6	1.08	.273	3.35	75	3.25	78	7.30	218.7
23	Jordan Zimmermann J. Zimmermann	86	92	.483	258	.517	257	4.01	1,173	8	4	0	1511.1	1,559	673	727	184	313	55	1	12	6,321	25	6.99	1.86	3.75	1.10	18.6	5.0	1.24	.299	4.33	98	3.87	96	9.28	21.5
24	Bartolo Colon B. Colon	85	94	.475	237	.525	227	4.15	928	7	5	0	1385.0	1,525	639	688	183	238	20	2	17	5,827	6	6.03	1.55	3.90	1.19	15.9	4.1	1.27	.301	4.47	104	4.04	100	9.91	-0.2
25	J.A. Happ	85	108	.440	271	.560	261	4.10	1,347	1	1	0	1490.1	1,424	679	727	197	533	31	5	13	6,337	40	8.13	3.22	2.53	1.19	21.3	8.4	1.31	.290	4.39	100	4.16	101	8.60	-3.6