The Boston Red Sox gave up their most runs in a game versus the Blue Jays on July 22, 2022, with 28 runs.

Interpreted as:

most runs given up regular-season game by red sox

	TEAM	R	DATE	TM		OPP	RESULT	ERA	SO	SHO	SV	IP	H	ER	HR	BB	HBP	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	H/9
1	Red Sox	28	7/22/2022	BOS	vs	TOR	L 5-28	27.00	9	0	0	9.0	29	27	5	5	1	0	63	2	9.00	5.00	1.80	5.00	14.3	7.9	3.78	.558	28.00	29.00
2	Red Sox	27	7/7/1923	BSA	@	CLE	L 3-27	0.00	1	0	0	8.0	24	0	0	14	1		61	0	1.13	15.75	0.07	0.00	1.6	23.0	4.75	.533	30.38	27.00
3	Red Sox	24	5/1/1929	BSA	vs	PHA	L 6-24	0.00	4	0	0	9.0	29	0	3	6	1		60	0	4.00	6.00	0.67	3.00	6.7	10.0	3.89	.565	24.00	29.00
4	Red Sox	24	9/28/1923	BSA	vs	NYY	L 4-24	0.00	7	0	0	9.0	30	0	2	6	0		62	0	7.00	6.00	1.17	2.00	11.3	9.7	4.00	.596	24.00	30.00
5	Red Sox	22	6/19/2000	BOS	vs	NYY	L 1-22	14.00	4	0	0	9.0	19	14	5	7	0	1	55	1	4.00	7.00	0.57	5.00	7.3	12.7	2.89	.359	22.00	19.00
6	Red Sox	22	5/31/1970	BOS	vs	CWS	L 13-22	18.00	9	0	0	9.0	24	18	1	3	0	1	55	1	9.00	3.00	3.00	1.00	16.4	5.5	3.00	.548	22.00	24.00
7	Americans	22	7/8/1902	BSA	vs	PHA	L 9-22	0.00	2	0	0	9.0	27	0	2	3	0	-13	0	0	2.00	3.00	0.67	2.00			3.33	-3.571	22.00	27.00
8	Red Sox	21	7/2/2016	BOS	vs	LAA	L 2-21	14.00	5	0	0	9.0	22	14	4	3	1	0	55	1	5.00	3.00	1.67	4.00	9.1	5.5	2.78	.429	21.00	22.00
9	Red Sox	21	5/20/1994	BOS	@	MIN	L 2-21	23.63	6	0	0	8.0	22	21	1	7	1	0	54	2	6.75	7.88	0.86	1.13	11.1	13.0	3.63	.538	23.63	24.75
10	Red Sox	21	6/14/1969	BOS	vs	OAK	L 7-21	16.00	6	0	0	9.0	25	16	3	9	1	0	62	0	6.00	9.00	0.67	3.00	9.7	14.5	3.78	.512	21.00	25.00
11	Red Sox	21	6/26/1960	BOS	@	CWS	L 7-21	23.63	8	0	0	8.0	22	21	3	5	1	0	53	1	9.00	5.63	1.60	3.38	15.1	9.4	3.38	.528	23.63	24.75
12	Red Sox	20	7/24/2024	BOS	@	COL	L 7-20	15.75	10	0	0	8.0	21	14	4	2	1	0	50	0	11.25	2.25	5.00	4.50	20.0	4.0	2.88	.515	22.50	23.63
13	Red Sox	20	8/31/2012	BOS	@	OAK	L 2-20	21.38	4	0	0	8.0	19	19	5	2	1	0	47	0	4.50	2.25	2.00	5.63	8.5	4.3	2.63	.400	22.50	21.38
14	Red Sox	20	8/21/2009	BOS	vs	NYY	L 11-20	19.00	5	0	0	9.0	23	19	2	5	0	0	54	4	5.00	5.00	1.00	2.00	9.3	9.3	3.11	.500	20.00	23.00
15	Red Sox	20	6/20/1980	BOS	vs	CAL	L 2-20	20.00	3	0	0	9.0	26	20	6	4	0	0	54	0	3.00	4.00	0.75	6.00	5.6	7.4	3.33	.488	20.00	26.00
16	Red Sox	20	7/7/1928	BSA	vs	DET	L 8-20	0.00	2	0	0	9.0	18	0	0	9	0		54	0	2.00	9.00	0.22	0.00	3.7	16.7	3.00	.419	20.00	18.00
17	Red Sox	19	9/26/2008	BOS	vs	NYY	L 8-19	18.00	5	0	0	9.0	20	18	3	5	2	0	54	1	5.00	5.00	1.00	3.00	9.3	9.3	2.78	.436	19.00	20.00
18	Red Sox	19	8/1/2002	BOS	@	TEX	L 7-19	21.38	5	0	0	8.0	20	19	6	5	2	0	50	0	5.63	5.63	1.00	6.75	10.0	10.0	3.13	.438	21.38	22.50
19	Red Sox	19	5/31/1980	BOS	vs	MIL	L 8-19	18.00	2	0	0	9.0	22	18	2	2	0	0	51	0	2.00	2.00	1.00	2.00	3.9	3.9	2.67	.444	19.00	22.00
20	Red Sox	19	4/10/1977	BOS	vs	CLE	L 9-19	11.00	6	0	0	9.0	19	11	1	5	0	1	51	0	6.00	5.00	1.20	1.00	11.8	9.8	2.67	.462	19.00	19.00
21	Red Sox	19	6/28/1962	BOS	vs	LAA	L 7-19	13.00	6	0	0	9.0	18	13	1	13	0	0	57	1	6.00	13.00	0.46	1.00	10.5	22.8	3.44	.459	19.00	18.00
22	Red Sox	19	5/18/1955	BOS	vs	CLE	L 0-19	18.00	5	0	0	9.0	19	18	3	9	1	1	56	0	5.00	9.00	0.56	3.00	8.9	16.1	3.11	.421	19.00	19.00
23	Red Sox	19	8/13/1940	BSA	@	NYY	L 8-19	0.00	1	0	0	6.0	15	0	3	4	1		41	2	1.50	6.00	0.25	4.50	2.4	9.8	3.17	.375	28.50	22.50
24	Red Sox	19	8/15/1922	BSA	vs	CWS	L 11-19	0.00	4	0	0	9.0	25	0	0	3	0		55	2	4.00	3.00	1.33	0.00	7.3	5.5	3.11	.521	19.00	25.00
25	Red Sox	18	6/13/2021	BOS	vs	TOR	L 4-18	16.00	7	0	0	9.0	20	16	8	4	0	0	49	0	7.00	4.00	1.75	8.00	14.3	8.2	2.67	.400	18.00	20.00