Johan Santana struck out the most batters in 2006, with 245 strikeouts.

	NAME	SO	SEASON	TM	G	W	L	W%	GS	ERA	CG	SHO	SV	IP	H	ER	R	HR	BB	HBP	GF	IBB	TBF	WP	K/9	BB/9	K/BB	HR/9	K%	BB%	WHIP	BABIP	RA	ERA-	FIP	FIP-	H/9	PRAA
1	Johan Santana J. Santana	245	2006	MIN	34	19	6	.760	34	2.77	1	0	0	233.2	186	72	79	24	47	4	0	0	923	4	9.44	1.81	5.21	0.92	26.5	5.1	1.00	.269	3.04	62	3.03	69	7.16	35.7
2	Aaron Harang A. Harang	216	2006	CIN	36	16	11	.593	35	3.76	6	2	0	234.1	242	98	109	28	56	8	0	8	993	6	8.30	2.15	3.86	1.08	21.8	5.6	1.27	.312	4.19	82	3.67	79	9.29	25.4
3	Jake Peavy J. Peavy	215	2006	SDP	32	11	14	.440	32	4.09	2	0	0	202.1	187	92	93	23	62	6	0	11	846	4	9.56	2.76	3.47	1.02	25.4	7.3	1.23	.304	4.14	99	3.50	81	8.32	19.4
4	John Smoltz J. Smoltz	211	2006	ATL	35	16	9	.640	35	3.49	3	1	0	232.0	221	90	93	23	55	9	0	4	960	5	8.19	2.13	3.84	0.89	22.0	5.7	1.19	.299	3.61	78	3.44	77	8.57	27
5	Carlos Zambrano C. Zambrano	210	2006	CHC	33	16	7	.696	33	3.41	0	0	0	214.0	162	81	91	20	115	9	0	4	917	9	8.83	4.84	1.83	0.84	22.9	12.5	1.29	.252	3.83	73	4.13	89	6.81	11.5
6	Jeremy Bonderman J. Bonderman	202	2006	DET	34	14	8	.636	34	4.08	0	0	0	214.0	214	97	104	18	64	3	0	7	903	3	8.50	2.69	3.16	0.76	22.4	7.1	1.30	.318	4.37	90	3.28	73	9.00	29.2
7	John Lackey J. Lackey	190	2006	LAA	33	13	11	.542	33	3.56	3	2	0	217.2	203	86	98	14	72	9	0	4	922	16	7.86	2.98	2.64	0.58	20.6	7.8	1.26	.297	4.05	79	3.35	75	8.39	27.3
8	Brett Myers B. Myers	189	2006	PHI	31	12	7	.632	31	3.91	1	0	0	198.0	194	86	93	29	63	3	0	3	833	3	8.59	2.86	3.00	1.32	22.7	7.6	1.30	.301	4.23	85	4.13	89	8.82	11.5
9	Bronson Arroyo B. Arroyo	184	2006	CIN	35	14	11	.560	35	3.29	3	1	0	240.2	222	88	98	31	64	5	0	7	992	6	6.88	2.39	2.88	1.16	18.5	6.5	1.19	.270	3.66	72	4.14	89	8.30	13.7
10	Chris Carpenter C. Carpenter	184	2006	STL	32	15	8	.652	32	3.09	5	3	0	221.2	194	76	81	21	43	10	0	3	896	3	7.47	1.75	4.28	0.85	20.5	4.8	1.07	.271	3.29	71	3.43	77	7.88	25.1
11	Javier Vazquez J. Vazquez	184	2006	CWS	33	11	12	.478	32	4.84	1	0	0	202.2	206	109	116	23	56	15	0	2	872	7	8.17	2.49	3.29	1.02	21.1	6.4	1.29	.308	5.15	102	3.85	81	9.15	19.5
12	Curt Schilling C. Schilling	183	2006	BOS	31	15	7	.682	31	3.97	0	0	0	204.0	220	90	90	28	28	3	0	1	834	1	8.07	1.24	6.54	1.24	21.9	3.4	1.22	.324	3.97	85	3.59	81	9.71	19.2
13	Jason Schmidt J. Schmidt	180	2006	SFG	32	11	9	.550	32	3.59	3	1	0	213.1	189	85	94	21	80	6	0	6	894	11	7.59	3.38	2.25	0.89	20.1	8.9	1.26	.277	3.97	79	3.94	89	7.97	11.7
14	Matt Cain M. Cain	179	2006	SFG	32	13	12	.520	31	4.15	1	1	0	190.2	157	88	93	18	87	6	1	1	818	9	8.45	4.11	2.06	0.85	21.9	10.6	1.28	.263	4.39	92	3.95	89	7.41	10.2
15	Andy Pettitte A. Pettitte	178	2006	HOU	36	14	13	.519	35	4.20	2	1	0	214.1	238	100	114	27	70	2	1	9	929	2	7.47	2.94	2.54	1.13	19.2	7.5	1.44	.324	4.79	95	4.12	90	9.99	10.6
16	Brandon Webb B. Webb	178	2006	ARI	33	16	8	.667	33	3.10	5	3	0	235.0	216	81	91	15	50	6	0	4	950	5	6.82	1.91	3.56	0.57	18.7	5.3	1.13	.287	3.49	66	3.17	68	8.27	38.1
17	Dan Haren D. Haren	176	2006	OAK	34	14	13	.519	34	4.12	2	0	0	223.0	224	102	109	31	45	10	0	6	930	10	7.10	1.82	3.91	1.25	18.9	4.8	1.21	.289	4.40	92	4.11	91	9.04	10.1
18	Felix Hernandez F. Hernandez	176	2006	SEA	31	12	14	.462	31	4.52	2	1	0	191.0	195	96	105	23	60	6	0	2	816	11	8.29	2.83	2.93	1.08	21.6	7.4	1.34	.312	4.95	103	3.90	88	9.19	11.2
19	Chris Capuano C. Capuano	174	2006	MIL	34	11	12	.478	34	4.03	3	2	0	221.1	229	99	108	29	47	9	0	4	936	7	7.08	1.91	3.70	1.18	18.6	5.0	1.25	.295	4.39	90	4.03	89	9.31	12.2
20	Randy Johnson R. Johnson	172	2006	NYY	33	17	11	.607	33	5.00	2	0	0	205.0	194	114	125	28	60	10	0	1	860	3	7.55	2.63	2.87	1.23	20.0	7.0	1.24	.281	5.49	110	4.26	94	8.52	5.8
21	Mike Mussina M. Mussina	172	2006	NYY	32	15	7	.682	32	3.51	1	0	0	197.1	184	77	88	22	35	5	0	1	804	3	7.84	1.60	4.91	1.00	21.4	4.4	1.11	.284	4.01	77	3.45	77	8.39	23.3
22	CC Sabathia	172	2006	CLE	28	12	11	.522	28	3.22	6	2	0	192.2	182	69	83	17	44	7	0	3	802	3	8.03	2.06	3.91	0.79	21.4	5.5	1.17	.294	3.88	71	3.29	74	8.50	24.5
23	Erik Bedard E. Bedard	171	2006	BAL	33	15	11	.577	33	3.76	0	0	0	196.1	196	82	92	16	69	5	0	0	844	6	7.84	3.16	2.48	0.73	20.3	8.2	1.35	.309	4.22	82	3.59	77	8.98	22.7
24	Ian Snell I. Snell	169	2006	PIT	32	14	11	.560	32	4.74	0	0	0	186.0	198	98	104	29	74	2	0	4	813	8	8.18	3.58	2.28	1.40	20.8	9.1	1.46	.314	5.03	108	4.57	103	9.58	-3.1
25	Dave Bush D. Bush	166	2006	MIL	34	12	11	.522	32	4.41	3	2	0	210.0	201	103	111	26	38	18	0	2	869	6	7.11	1.63	4.37	1.11	19.1	4.4	1.14	.282	4.76	98	3.97	88	8.61	13