Cy Young has lost the most career games, with 316 games.

which pitcher has the most career losses

Interpreted as:

Which pitcher has the most career regular-season losses?

NAME	L	G	W	L%	W%	GS	CG	GF	SHO	SV	IP	H	TBF	R	ER	HR	BB	IBB	HBP	SO	WP	ERA	WHIP	K/9	H/9	BB/9	K/BB	ERA-	FIP	FIP-	PRAA
Cy Young	316	906	511	.382	.618	815	749	84	76	17	7356.0	7,092	29,565	3,167	2,147	138	1,217		161	2,803	156	2.63	1.13	3.43	8.68	1.49	2.30	74	2.84	79	620
Pud Galvin	308	697	361	.460	.540	681	639	18	57	1	5941.1	6,352	25,160	3,315	1,895	121	744		54	1,799	220	2.87	1.19	2.73	9.62	1.13	2.42	94	2.97	95	94.5
Nolan Ryan	292	807	324	.474	.526	773	222	13	61	3	5386.0	3,923	22,575	2,178	1,911	321	2,795	78	158	5,714	277	3.19	1.25	9.55	6.56	4.67	2.04	90	2.96	83	370.2
Walter Johnson	279	802	417	.401	.599	666	531	127	110	34	5914.1	4,913	23,405	1,902	1,424	97	1,363		205	3,509	154	2.17	1.06	5.34	7.48	2.07	2.57	68	2.42	76	472.8
Phil Niekro	274	864	318	.463	.537	716	245	83	45	29	5404.0	5,044	22,677	2,337	2,012	482	1,809	86	123	3,342	226	3.35	1.27	5.57	8.40	3.01	1.85	87	3.61	95	116.1
Gaylord Perry	265	777	314	.458	.542	690	303	33	53	10	5350.0	4,938	21,953	2,128	1,846	399	1,379	164	108	3,534	160	3.11	1.18	5.95	8.31	2.32	2.56	85	3.06	85	312.9
Don Sutton	256	774	324	.441	.559	756	178	12	58	5	5282.1	4,692	21,631	2,104	1,914	472	1,343	102	82	3,574	112	3.26	1.14	6.09	7.99	2.29	2.66	92	3.23	90	181.2
Jack Powell	254	578	245	.509	.491	516	422	57	46	15	4389.0	4,319	17,896	1,991	1,450	110	1,021		120	1,621	67	2.97	1.22	3.32	8.86	2.09	1.59	95	3.01	97	35
Eppa Rixey	251	692	266	.485	.515	554	290	99	37	14	4494.2	4,633	18,754	1,986	1,572	93	1,082		76	1,350	97	3.15	1.27	2.70	9.28	2.17	1.25	88	3.29	91	162.7
Bert Blyleven	250	692	287	.466	.534	685	242	3	60	0	4970.0	4,632	20,491	2,029	1,830	430	1,322	71	155	3,701	114	3.31	1.20	6.70	8.39	2.39	2.80	85	3.18	82	368.6
Robin Roberts	245	676	286	.461	.539	609	305	49	45	25	4688.2	4,582	19,174	1,962	1,774	505	902	69	54	2,357	33	3.41	1.17	4.52	8.80	1.73	2.61	89	3.50	91	179.6
Warren Spahn	245	750	363	.403	.597	665	382	67	63	28	5243.2	4,830	21,547	2,016	1,798	434	1,434	60	42	2,583	81	3.09	1.19	4.43	8.29	2.46	1.80	84	3.44	94	124.4
Steve Carlton	244	741	329	.426	.574	709	254	13	55	2	5217.2	4,672	21,683	2,130	1,864	414	1,833	150	53	4,136	183	3.22	1.25	7.13	8.06	3.16	2.26	87	3.14	86	271.5
Early Wynn	244	691	300	.449	.551	611	289	67	49	16	4564.0	4,291	19,408	2,037	1,796	338	1,775	36	64	2,334	51	3.54	1.33	4.60	8.46	3.50	1.31	94	3.64	97	56.4
Jim Kaat	237	898	283	.456	.544	625	180	102	31	17	4530.1	4,620	19,023	2,038	1,738	395	1,083	116	122	2,461	128	3.45	1.26	4.89	9.18	2.15	2.27	93	3.41	91	165.8
Frank Tanana	236	638	240	.496	.504	616	143	10	34	1	4188.1	4,063	17,641	1,910	1,704	448	1,255	116	129	2,773	119	3.66	1.27	5.96	8.73	2.70	2.21	94	3.78	96	66.4
Gus Weyhing	232	540	264	.468	.532	505	449	34	28	4	4337.0	4,576	19,188	2,796	1,872	120	1,570		277	1,667	240	3.88	1.42	3.46	9.50	3.26	1.06	96	3.82	97	55.7
Tommy John	231	760	288	.445	.555	700	162	22	46	3	4710.1	4,783	19,692	2,017	1,749	302	1,259	102	98	2,245	187	3.34	1.28	4.29	9.14	2.41	1.78	90	3.37	89	208.3
Bob Friend	230	602	197	.539	.461	497	163	56	36	10	3611.0	3,772	15,214	1,652	1,438	286	894	115	46	1,734	50	3.58	1.29	4.32	9.40	2.23	1.94	94	3.35	89	172.2
Ted Lyons	230	594	260	.469	.531	484	356	91	27	25	4161.0	4,489	17,797	2,056	1,696	222	1,121		31	1,073	55	3.67	1.35	2.32	9.71	2.42	0.96	85	4.01	95	91.7
Greg Maddux	227	744	355	.390	.610	740	109	3	35	0	5008.1	4,726	20,421	1,981	1,756	353	999	177	137	3,371	70	3.16	1.14	6.06	8.49	1.80	3.37	76	3.25	78	519.5
Fergie Jenkins	226	664	284	.443	.557	594	267	37	49	7	4500.2	4,142	18,400	1,853	1,669	484	997	116	84	3,192	62	3.34	1.14	6.38	8.28	1.99	3.20	87	3.27	88	222.9
Red Ruffing	225	624	273	.452	.548	538	335	69	45	18	4344.0	4,284	18,546	2,115	1,833	254	1,541		58	1,987	46	3.80	1.34	4.12	8.88	3.19	1.29	91	3.93	95	82.3
Tim Keefe	225	600	342	.397	.603	594	554	7	39	2	5049.2	4,438	20,941	2,470	1,474	75	1,233		83	2,564	240	2.63	1.12	4.57	7.91	2.20	2.08	79	2.92	87	239.2
Bobo Newsom	222	600	211	.513	.487	483	246	71	31	21	3759.1	3,769	16,467	1,908	1,664	206	1,732		61	2,082	60	3.98	1.46	4.98	9.02	4.15	1.20	95	3.81	92	144.5

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MLB 2023 Division Standings

	NL East	W	L	PCT	GB
1	Braves	104	58	.642
2	Phillies	90	72	.556	14.0
	AL East	W	L	PCT	GB
1	Orioles	101	61	.623
2	Rays	99	63	.611	2.0
	NL West	W	L	PCT	GB
1	Dodgers	100	62	.617
2	Diamondbacks	84	78	.519	16.0
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1	Astros	90	72	.556
2	Rangers	90	72	.556
	AL Central	W	L	PCT	GB
1	Twins	87	75	.537
2	Tigers	78	84	.481	9.0