Answered January 12th, 2020

Since 1960, Chris Davis has the highest 100 * strikeouts per plate appearance when making 4,000+ plate appearances, with 32.91.

most 100*so/pa in a career 4000 pa since 1960
Interpreted as:
most 100*so/pa by a player in a career 4000 or more pa since 1960

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