Answered January 12th, 2020

Since 1960, Melvin Nieves has the highest 100 * strikeouts per plate appearance with 400+ plate appearances in a season, with 38.77 in 1997.

most 100*so/pa in a season 400 pa since 1960
Interpreted as:
most 100*so/pa by a player in a season 400 or more pa since 1960

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