Answered January 12th, 2020

Since 1913, Mark McGwire has the highest 100 * isolated power - batting average when making 6,000+ plate appearances, with 6.26.

most 100 * (iso - ba) in a career 6000 pa since 1913
Interpreted as:
most 100 * (iso - ba) by a player in a career 6000 or more pa since 1913

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