Reggie Jackson has the most career strikeouts, with 2,597 strikeouts.

Interpreted as:

most strike-outs by a player in first inning

	NAME	SO	G	AB	R	H	2B	3B	HR	RBI	BB	HBP	SB	CS	PA	TB	XBH	SH	SF	IBB	GIDP	AVG	OBP	SLG	OPS	WRC	WRAA	WOBA	WRC+	BRAA
1	Reggie Jackson R. Jackson	2,597	2,820	9,864	1,551	2,584	463	49	563	1,702	1,375	96	228	115	11,416	4,834	1,075	13	68	164	183	.262	.356	.490	.846	1749	503	.374	139	497.6
2	Jim Thome J. Thome	2,548	2,543	8,422	1,583	2,328	451	26	612	1,699	1,747	69	19	20	10,313	4,667	1,089	1	74	173	165	.276	.402	.554	.956	1925	653.9	.406	145	589.5
3	Adam Dunn A. Dunn	2,379	2,001	6,883	1,097	1,631	334	10	462	1,168	1,317	86	63	25	8,328	3,371	806	2	40	122	100	.237	.364	.490	.854	1285	297.9	.367	123	240
4	Sammy Sosa S. Sosa	2,306	2,354	8,813	1,475	2,408	379	45	609	1,667	929	59	234	107	9,896	4,704	1,033	17	78	154	202	.273	.344	.534	.878	1559	345.1	.370	124	307.3
5	Alex Rodriguez A. Rodriguez	2,287	2,784	10,566	2,021	3,115	548	31	696	2,086	1,338	176	329	76	12,207	5,813	1,275	16	111	97	261	.295	.380	.550	.930	2178	690.1	.395	141	629.5
6	Miguel Cabrera M. Cabrera	2,105	2,797	10,356	1,551	3,174	627	17	511	1,881	1,258	74	40	21	11,796	5,368	1,155	5	103	238	364	.306	.382	.518	.901	1981	585.3	.382	139	547.8
7	Andres Galarraga A. Galarraga	2,003	2,257	8,096	1,195	2,333	444	32	399	1,425	583	178	128	81	8,916	4,038	875	1	58	106	179	.288	.347	.499	.846	1355	286.5	.365	118	193.8
8	Giancarlo Stanton G. Stanton	1,989	1,672	6,097	916	1,570	308	11	433	1,119	787	54	42	15	6,977	3,199	752	0	39	89	154	.258	.346	.525	.870	1107	298.3	.368	135	292.3
9	Justin Upton J. Upton	1,971	1,845	6,721	1,058	1,754	350	38	325	1,003	785	78	151	59	7,646	3,155	713	3	59	49	142	.261	.342	.469	.812	1082	194.2	.350	117	155.9
10	Paul Goldschmidt P. Goldschmidt	1,942	2,020	7,458	1,260	2,154	469	24	370	1,223	1,078	51	174	36	8,643	3,781	863	0	56	121	173	.289	.380	.507	.887	1448	435.7	.377	138	391.3
11	Jose Canseco J. Canseco	1,942	1,887	7,057	1,186	1,877	340	14	462	1,407	906	84	200	88	8,129	3,631	816	1	81	63	178	.266	.353	.515	.867	1293	321.2	.375	130	300.8
12	Willie Stargell W. Stargell	1,936	2,360	7,927	1,194	2,232	423	55	475	1,540	937	78	17	16	9,026	4,190	953	9	75	227	143	.282	.360	.529	.889	1471	511.5	.387	145	459.3
13	Mark Reynolds M. Reynolds	1,927	1,688	5,432	794	1,283	253	14	298	871	707	56	64	31	6,243	2,458	565	3	45	26	117	.236	.328	.453	.780	821	94.7	.338	103	24.8
14	Nelson Cruz N. Cruz	1,916	2,055	7,501	1,090	2,053	372	15	464	1,325	738	86	84	32	8,387	3,847	851	2	60	78	179	.274	.343	.513	.856	1294	313.6	.363	129	286.2
15	Curtis Granderson C. Granderson	1,916	2,057	7,236	1,217	1,800	346	95	344	937	924	67	153	50	8,306	3,368	785	30	49	31	64	.249	.337	.465	.803	1149	173.1	.347	115	147.8
16	Mike Cameron M. Cameron	1,901	1,955	6,839	1,064	1,700	383	59	278	968	867	87	297	83	7,884	3,035	720	31	60	19	114	.249	.338	.444	.782	1043	70.3	.341	107	69.2
17	Mike Schmidt M. Schmidt	1,883	2,404	8,352	1,506	2,234	408	59	548	1,595	1,507	79	174	92	10,062	4,404	1,015	16	108	201	156	.267	.380	.527	.908	1717	591	.395	147	539.8
18	Fred McGriff F. McGriff	1,882	2,460	8,757	1,349	2,490	441	24	493	1,550	1,305	39	72	38	10,174	4,458	958	2	71	171	226	.284	.377	.509	.886	1678	454.1	.383	134	415.9
19	Tony Perez T. Perez	1,867	2,777	9,778	1,272	2,732	505	79	379	1,652	925	43	49	33	10,861	4,532	963	9	106	150	268	.279	.341	.463	.804	1511	343.8	.356	121	265.2
20	Chris Davis C. Davis	1,852	1,417	4,978	707	1,160	228	5	295	780	555	58	19	11	5,630	2,283	528	1	38	50	62	.233	.315	.459	.774	713	61.5	.332	106	31.8
21	Andrew McCutchen A. McCutchen	1,850	2,214	8,183	1,270	2,231	443	50	327	1,126	1,153	94	220	89	9,508	3,755	820	3	75	70	140	.273	.366	.459	.825	1420	315.7	.357	126	293.1
22	Ryan Howard R. Howard	1,843	1,572	5,707	848	1,475	277	21	382	1,194	709	59	12	5	6,530	2,940	680	0	55	154	116	.258	.343	.515	.859	976	212.1	.361	121	175.3
23	Bobby Abreu B. Abreu	1,840	2,425	8,480	1,453	2,470	574	59	288	1,363	1,476	33	400	128	10,081	4,026	921	7	85	115	165	.291	.395	.475	.870	1648	417.8	.378	129	382
24	Derek Jeter D. Jeter	1,840	2,747	11,195	1,923	3,465	544	66	260	1,311	1,082	170	358	97	12,602	4,921	870	97	58	39	287	.310	.377	.440	.817	1877	346.6	.360	119	305.9
25	Dave Kingman D. Kingman	1,816	1,941	6,677	901	1,575	240	25	442	1,210	608	53	85	49	7,429	3,191	707	16	75	72	139	.236	.302	.478	.780	960	139.8	.343	113	108.5