Answered January 12th, 2020

Alex Cobb has the highest K/9 in a game with 4.0+ innings pitched, with 25.07 per nine innings versus the Padres on May 10, 2013.

what pitcher has the highest k/9 rate in a game; minimum 4 ip
Interpreted as:
What pitcher has the highest k/9 rate in a regular-season game; minimum 4 ip?

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