QMMM Holdings Limited Ordinary Shares (QMMM) has had the highest return this year by a US stock in the Nasdaq Composite (IXIC), returning 9,155.8%.

ASSET	YEAR	% RETURN
QMMM Holdings Limited Ordinary Shares (QMMM)	2025	9,155.81%
Regencell Bioscience (RGC)	2025	8,844.61%
Diginex Limited Ordinary Shares (DGNX)	2025	1,907.51%
Abivax SA American Depositary Shares (ABVX)	2025	1,556.35%
FiEE (FIEE)	2025	1,014.68%
Abits (ABTS)	2025	910.97%
DeFi Development (DFDV)	2025	877.86%
Oncology Institute (TOI)	2025	860.78%
Newegg Commerce (NEGG)	2025	801.88%
Relmada Therapeutics (RLMD)	2025	751.97%
XMax (XWIN)	2025	719.7%
Palvella Therapeutics (PVLA)	2025	714.21%
Cidara Therapeutics (CDTX)	2025	710.51%
Celcuity LLC (CELC)	2025	644.97%
Nanobiotix (NBTX)	2025	558.84%
Charming Medical Limited Class A Ordinary Shares (MCTA)	2025	539.54%
Lizhi (SOGP)	2025	527.63%
Sandisk (SNDK)	2025	499.46%
GRAIL, LLC (GRAL)	2025	451.46%
TMC the metals (TMC)	2025	451.32%
Invivyd (IVVD)	2025	431.91%
Inhibrx Biosciences (INBX)	2025	427.56%
Hycroft Mining (HYMC)	2025	422.57%
JFB Construction Holdings Class A Common Stock (JFB)	2025	419.94%
Global Interactive Technologies (GITS)	2025	418.67%