NVIDIA (NVDA) has had the highest return between 2021 and 2025 by a mega-cap US stock, returning 1,295.9%.

ASSET	YEARS	% RETURN
NVIDIA (NVDA)	2021-2025	1,295.91%
Applovin (APP)	2021-2025	888.49%
Broadcom (AVGO)	2021-2025	885.43%
Palantir Technologies (PLTR)	2021-2025	660.18%
Eli Lilly and (LLY)	2021-2025	529.79%
GE Aerospace (GE)	2021-2025	434.54%
Alphabet Inc Class A (GOOGL)	2021-2025	267.6%
Caterpillar (CAT)	2021-2025	262.54%
Oracle (ORCL)	2021-2025	260.66%
Goldman Sachs (GS)	2021-2025	260.44%
HSBC Holdings PLC ADR (HSBC)	2021-2025	259.21%
Lam Research (LRCX)	2021-2025	250.52%
Exxon Mobil (XOM)	2021-2025	244.09%
Wells Fargo (WFC)	2021-2025	232.43%
American Express (AXP)	2021-2025	224.77%
Applied Materials (AMAT)	2021-2025	220.79%
Micron Technology (MU)	2021-2025	217.77%
International Business Machines (IBM)	2021-2025	214.8%
Morgan Stanley (MS)	2021-2025	198.85%
Taiwan Semiconductor Manufacturing (TSM)	2021-2025	186.69%
JPMorgan Chase (JPM)	2021-2025	181.34%
Raytheon Technologies (RTX)	2021-2025	168.84%
AbbVie (ABBV)	2021-2025	156.35%
Walmart (WMT)	2021-2025	155.62%
Costco Wholesale (COST)	2021-2025	150.53%

Mega-cap stocks are treated as having a market cap of $200B+.