Brera Holdings PLC Class B Ordinary Shares (BREA) has had the highest return since 2021 by a US stock, returning 513,900%.

ASSET	% RETURN
Brera Holdings PLC Class B Ordinary Shares (BREA)	513,900%
Diversified Energy (DEC)	428,008.11%
MDxHealth SA ADR (MDXH)	327,172.73%
DevvStream Corp Common Stock (DEVS)	199,900%
BioNexus Gene Lab Corp Common stock (BGLC)	178,595.65%
Applied Digital (APLD)	83,153.33%
ZTST (ZTST)	30,631.89%
Castellum (CTM)	23,536.36%
Heart Test Laboratories Inc Common Stock (HSCS)	7,752.94%
Azitra (AZTR)	6,382.14%
Regencell Bioscience (RGC)	5,042.5%
Guardforce AI (GFAI)	4,121.15%
Foremost Lithium Resource & Technology Ltd Common stock (FMST)	3,919.2%
Celestica (CLS)	3,888.83%
QMMM Holdings Limited Ordinary Shares (QMMM)	3,880%
Terrestrial Energy (IMSRW)	3,747.62%
Blue Gold Limited Warrant (BGLWW)	3,000%
Lottery (SEGG)	2,263.64%
VisionWave Holdings, Inc Warrant (VWAVW)	1,983.33%
Vista Oil Gas ADR (VIST)	1,864.48%
Comfort Systems USA (FIX)	1,843.98%
New Era Energy & Digital (NUAIW)	1,776.85%
Power Solutions International, Inc Common Stock (PSIX)	1,743.03%
Euroseas (ESEA)	1,735.58%
Sezzle (SEZL)	1,711.66%