Celestica (CLS) has had the highest return between 2021 and 2025 by a large-cap US stock, returning 3,492%.

ASSET	YEARS	% RETURN
Celestica (CLS)	2021-2025	3,492.02%
Sterling Construction (STRL)	2021-2025	1,648.39%
Comfort Systems USA (FIX)	2021-2025	1,642.19%
NVIDIA (NVDA)	2021-2025	1,329.87%
Dillard's (DDS)	2021-2025	1,181.7%
Carpenter Technology (CRS)	2021-2025	1,087.32%
Credo Technology (CRDO)	2021-2025	1,081.4%
Super Micro Computer (SMCI)	2021-2025	1,003.46%
Oklo (OKLO)	2021-2025	916.4%
Permian Resources (PR)	2021-2025	895.74%
Vistra Energy (VST)	2021-2025	869.88%
Constellation Energy (CEG)	2021-2025	812.68%
Fortress Transp & Infra Inv (FTAI)	2021-2025	811.73%
Embraer SA ADR (ERJ)	2021-2025	808.73%
Vertiv (VRT)	2021-2025	775.73%
Broadcom (AVGO)	2021-2025	758.51%
Applovin (APP)	2021-2025	694.5%
YPF Sociedad Anonima (YPF)	2021-2025	671.01%
Palantir Technologies (PLTR)	2021-2025	619.95%
Flex (FLEX)	2021-2025	618.81%
Arista Networks (ANET)	2021-2025	617.02%
Howmet Aerospace (HWM)	2021-2025	616.23%
Targa Resources (TRGP)	2021-2025	599.86%
EMCOR (EME)	2021-2025	583.71%
Mueller Industries (MLI)	2021-2025	548.76%

Large-cap stocks are treated as having a market cap of $10B+.