Hirequest (HQI) had the highest return between 2000 and 2005 by a US stock, returning 43,752,250%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2000-2005	43,752,250%
InterContinental Hotels Group PLC ADR (IHG)	2000-2005	9,399,400%
Cemtrex (CETX)	2000-2005	4,938,903.31%
Perspective Therapeutics (CATX)	2000-2005	2,416,566.67%
National Grid PLC ADR (NGG)	2000-2005	864,752.94%
Alto Ingredients (ALTO)	2000-2005	794,931.49%
Houston American Energy (HUSA)	2000-2005	787,269.02%
Inseego (INSG)	2000-2005	201,733.33%
NextTrip (NTRP)	2000-2005	191,900%
Cryoport (CYRX)	2000-2005	71,251.35%
ImmunoPrecise Antibodies (HYFT)	2000-2005	64,185.71%
Gladstone Capital (GLAD)	2000-2005	43,148.37%
Insmed (INSM)	2000-2005	24,867.49%
OPTIMIZERx (OPRX)	2000-2005	13,900%
NanoViricides (NNVC)	2000-2005	12,360%
Xcel Brands (XELB)	2000-2005	9,400%
First Majestic Silver (AG)	2000-2005	9,373.78%
TherapeuticsMD (TXMD)	2000-2005	7,400.01%
Dmc Global (BOOM)	2000-2005	4,728.89%
CBAK Energy Technology (CBAT)	2000-2005	4,320%
Monster Beverage (MNST)	2000-2005	3,581.39%
Protalix Biotherapeutics (PLX)	2000-2005	3,300%
Broadwind Energy (BWEN)	2000-2005	3,260.13%
Americas Silver (USAS)	2000-2005	3,136.84%
Interlink Electronics (LINK)	2000-2005	2,995.15%