Since 2015-16, Giannis Antetokounmpo has the most games with 20+ points, with 492 games.

Interpreted as:

most 20 or more point regular-season games by a player since 2016

NAME	GP	PTS	MPG	PPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	REB	AST	STL	BLK	TOV	PF	+/-
Giannis Antetokounmpo	492	14,965	34.8	30.4	11.5	5.7	1.3	1.3	3.5	11.1	19.3	57.5	0.9	2.9	30.5	7.4	10.4	70.7	17,113	5,641	2,817	630	648	1,699	1,541	+2991
LeBron James	484	13,946	36.6	28.8	8.2	8.2	1.3	0.7	3.7	10.9	20.3	53.6	2.2	5.9	37.1	4.8	6.7	72.2	17,729	3,973	3,945	627	333	1,801	847	+2368
Damian Lillard	477	14,343	36.6	30.1	4.6	7.0	1.0	0.3	2.9	9.5	20.5	46.3	3.8	9.6	39.6	7.2	7.9	91.2	17,469	2,175	3,343	481	157	1,399	884	+1827
James Harden	474	14,943	37.3	31.5	6.8	9.0	1.7	0.7	4.6	9.3	20.4	45.7	3.8	10.1	37.9	9.0	10.4	86.5	17,666	3,206	4,264	787	332	2,158	1,275	+2562
DeMar DeRozan	470	13,097	36.5	27.9	5.0	5.1	1.1	0.4	2.2	9.9	19.4	50.9	0.7	2.0	33.9	7.4	8.6	86.2	17,143	2,362	2,380	519	166	1,037	1,037	+873
Stephen Curry	438	13,471	34.3	30.8	5.3	6.0	1.4	0.3	3.2	10.2	20.5	49.8	5.3	11.9	44.6	5.0	5.5	91.8	15,043	2,335	2,622	618	113	1,389	906	+3899
Kevin Durant	430	12,452	35.9	29.0	7.3	5.4	0.9	1.4	3.2	10.2	19.3	53.2	2.3	5.8	40.4	6.1	6.9	89.1	15,441	3,138	2,306	373	581	1,364	866	+2944
Devin Booker	409	12,066	36.2	29.5	4.3	5.5	0.9	0.3	3.2	10.4	20.9	49.7	2.6	6.6	39.0	6.2	7.1	87.3	14,808	1,774	2,244	377	129	1,329	1,234	+1038
Anthony Davis	397	11,816	36.7	29.8	11.9	2.9	1.4	2.3	2.3	11.0	20.3	54.2	0.8	2.4	32.9	7.0	8.7	80.7	14,572	4,707	1,141	565	917	900	953	+1228
Paul George	390	10,898	35.9	27.9	6.8	4.0	1.8	0.4	2.9	9.4	19.6	48.1	3.7	8.5	43.2	5.4	6.2	87.0	14,002	2,649	1,576	698	169	1,136	1,077	+2355
Russell Westbrook	386	10,975	36.1	28.4	9.2	9.6	1.7	0.4	4.6	10.3	21.7	47.3	1.8	5.1	34.4	6.1	7.9	76.9	13,943	3,570	3,707	641	139	1,779	1,095	+1085
Karl-Anthony Towns	382	10,330	35.1	27.0	11.3	3.4	0.9	1.3	2.7	9.9	18.0	55.2	2.1	4.8	42.9	5.2	6.1	83.9	13,426	4,329	1,314	327	493	1,050	1,305	+1191
Bradley Beal	379	10,829	36.8	28.6	4.6	4.9	1.2	0.4	2.9	10.4	20.8	50.0	2.8	6.9	39.8	5.0	6.0	84.2	13,946	1,735	1,857	469	168	1,085	924	+416
Nikola Jokic	377	10,497	34.5	27.8	12.2	7.8	1.4	0.8	3.3	10.7	18.2	58.7	1.4	3.6	38.2	5.1	6.1	83.4	13,006	4,581	2,923	522	304	1,258	1,022	+2457
CJ McCollum	374	9,835	36.0	26.3	4.2	4.6	1.0	0.5	2.0	9.9	19.8	50.3	3.5	7.7	45.4	2.9	3.6	83.0	13,463	1,559	1,715	370	177	746	858	+1612
Kyrie Irving	354	10,136	35.7	28.6	4.3	5.9	1.3	0.5	2.4	10.6	20.7	51.1	3.2	7.5	42.5	4.3	4.7	90.7	12,642	1,529	2,075	464	187	854	861	+1907
Joel Embiid	349	10,848	33.1	31.1	11.6	3.7	1.0	1.7	3.4	10.2	19.5	52.5	1.3	3.6	36.5	9.3	11.1	83.8	11,563	4,046	1,303	334	591	1,201	1,081	+2364
Donovan Mitchell	342	9,862	35.2	28.8	4.5	4.8	1.4	0.3	2.9	10.2	21.3	48.0	3.4	8.7	39.1	5.0	5.9	84.9	12,043	1,530	1,632	495	114	978	855	+1935
Luka Doncic	340	10,573	35.8	31.1	9.0	8.6	1.2	0.5	4.1	10.6	21.8	48.5	3.2	9.1	35.8	6.7	8.8	75.3	12,179	3,071	2,926	412	160	1,388	818	+1186
Jimmy Butler	335	8,830	36.4	26.4	6.2	5.4	1.9	0.5	1.9	8.5	16.6	51.4	1.1	3.0	36.8	8.2	9.6	85.8	12,201	2,069	1,813	624	163	649	517	+1373
Kawhi Leonard	331	9,106	34.6	27.5	6.7	3.9	1.8	0.7	2.0	9.8	18.8	52.0	2.2	5.3	42.4	5.7	6.5	88.3	11,452	2,229	1,288	582	216	663	578	+2389
Jayson Tatum	318	9,187	35.8	28.9	7.9	4.0	1.1	0.7	2.5	10.0	20.4	49.0	3.3	8.2	40.1	5.6	6.6	85.7	11,394	2,510	1,261	364	217	808	683	+2557
Zach LaVine	314	8,682	35.7	27.6	4.6	4.3	1.0	0.3	2.9	9.8	19.4	50.2	3.2	7.6	41.9	4.9	5.9	83.8	11,214	1,460	1,348	299	106	910	713	-146
Julius Randle	295	7,854	35.6	26.6	9.9	4.2	0.8	0.4	3.1	9.6	18.6	51.3	2.0	5.2	38.2	5.5	7.1	77.6	10,495	2,927	1,242	234	121	921	940	+881
Trae Young	291	8,721	35.6	30.0	3.8	9.9	1.0	0.2	4.2	9.5	20.5	46.4	3.2	8.2	38.9	7.7	8.8	88.0	10,357	1,096	2,889	296	49	1,219	517	+676