Latrell Sprewell has the most games with 48+ minutes played in a season, with 21 games in 1993-94.

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most 48 minutes games by a player in a season
Interpreted as:
most 48 or more minutes games by a player in a season
1993-94Sprewell1999-00Payton2009-10Ellis2004-05James1999-00Finley1992-93Skiles1997-98Finley1995-96Finley2002-03Rose1991-92Rodman1991-92Mullin1990-91Mitchell2005-06Iverson2001-02Finley1994-95Majerle2010-11Ellis2005-06Peterson2001-02Mobley1996-97Rice1996-97Sprewell1996-97Ellis1993-94Majerle1990-91Skiles1990-91Richardson1987-88Barkley2114131313131212111111111010109999999999
NAMESEASONTMGPMINMPGPPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%PTSREBASTSTLBLKTOVPF+/-
Latrell SprewellLatrell Sprewell1993-94GSWGSW211,02148.623.15.65.22.41.42.68.019.641.12.05.437.75.06.775.048611810951295549
Gary PaytonGary Payton1999-00SEASEA1468548.927.18.29.52.10.42.410.523.445.02.56.936.13.65.467.13801151332963426-25
Monta EllisMonta Ellis2009-10GSWGSW1362948.432.33.86.52.70.64.512.426.746.41.54.731.16.18.571.242049853585945-3
LeBron JamesLeBron James2004-05CLECLE1363749.034.58.86.92.71.24.512.025.846.62.15.935.18.510.977.54491159035155829+22
Michael FinleyMichael Finley1999-00DALDAL1362848.326.87.97.21.70.52.610.424.841.91.54.235.24.55.385.5348103932263422-8
Scott SkilesScott Skiles1992-93ORLORL1364149.321.24.99.41.40.13.37.314.550.31.23.832.75.35.989.6275641221814342
Michael FinleyMichael Finley1997-98DALDAL1259449.526.56.15.11.80.63.310.323.344.31.13.630.24.85.881.431873612274023-20
Michael FinleyMichael Finley1995-96PHXPHX1258348.618.36.05.21.70.41.57.114.050.60.61.831.83.55.070.021972622051825
Jalen RoseJalen Rose2002-03CHICHI1154249.327.35.86.11.40.64.29.921.945.22.56.537.55.05.984.630064671574633-25
Dennis RodmanDennis Rodman1991-92DETDET1153348.511.621.92.70.81.82.34.88.655.80.51.731.61.52.461.5128241309202533
Chris MullinChris Mullin1991-92GSWGSW1154449.527.57.03.51.90.82.810.521.249.41.33.141.25.36.778.430277392193132
Sam MitchellSam Mitchell1990-91MINMIN1156050.919.39.41.81.10.21.47.115.844.80.00.30.05.16.775.7212103201221551
Allen IversonAllen Iverson2005-06PHIPHI1049849.832.64.09.11.80.13.911.227.241.20.83.125.89.411.879.732640911813917-17
Michael FinleyMichael Finley2001-02DALDAL1049949.927.08.33.70.50.42.310.821.450.51.43.836.84.04.588.92708337542330+30
Dan MajerleDan Majerle1994-95PHXPHX1048648.619.07.15.70.90.81.86.715.343.82.57.533.33.14.077.51907157981820
Monta EllisMonta Ellis2010-11GSWGSW943948.733.04.18.13.00.33.912.425.249.33.05.851.95.17.073.029737732733529+39
Morris PetersonMorris Peterson2005-06TORTOR944349.224.25.93.41.40.31.78.418.346.12.96.644.14.45.285.121853311331532-21
Cuttino MobleyCuttino Mobley2001-02HOUHOU945550.627.64.63.01.70.71.910.323.444.12.25.640.04.75.289.424841271561725+21
Glen RiceGlen Rice1996-97CHACHA944149.030.85.41.71.00.32.410.221.148.42.45.345.87.99.384.52774915932216+56
Latrell SprewellLatrell Sprewell1996-97GSWGSW945050.026.96.18.21.20.75.19.421.643.81.75.331.36.37.683.824255741164618-10
Dale EllisDale Ellis1996-97DENDEN943748.624.65.83.90.90.02.89.121.143.24.19.344.02.22.976.92215235802527+9
Dan MajerleDan Majerle1993-94PHXPHX943548.318.85.14.81.41.02.26.416.239.73.38.639.02.64.260.516946431392024
Scott SkilesScott Skiles1990-91ORLORL943748.627.44.713.02.20.04.08.918.348.52.85.352.16.97.492.5247421172003628
Pooh RichardsonPooh Richardson1990-91MINMIN944149.020.24.09.31.90.12.19.419.049.70.31.325.01.01.952.918236841711921
Charles BarkleyCharles Barkley1987-88PHIPHI944048.935.016.23.91.71.43.911.922.652.70.92.930.810.314.173.23151463515133531
StatMuse has game-level data for minutes played going back to the 1982-83 season.