Wilt Chamberlain had the most games with 65+ points, with 15 games.

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most 65 point games in nba career
Interpreted as:
most 65 or more point regular-season games by a player in NBA career
Wilt ChamberlainWilt Chamberlain151,06348.970.926.31.828.244.663.214.522.265.27343942725
Kobe BryantKobe Bryant214645.973.
Devin BookerDevin Booker17045.
David RobinsonDavid Robinson17144.
Michael JordanMichael Jordan16950.
David ThompsonDavid Thompson17343.
Pete MaravichPete Maravich16843.
Elgin BaylorElgin Baylor17145.