Anthony Davis has the most games with 45+ points and 15+ rebounds in a season, with 4 games in 2017-18.

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most games with 45 points 15 rebounds in a season
Interpreted as:
most games by a player with 45 or more points 15 or more rebounds in a season
2017-18Davis2016-17Davis2020-21Embiid2018-19Davis2016-17Westbrook1989-90Malone1987-88Barkley2020-21Jokic2019-20Harden2018-19Antetokounmpo2018-19Harden2018-19George2017-18Towns2017-18Embiid2016-17Cousins2016-17Harden2016-17Towns2015-16Davis2014-15Westbrook2014-15Gasol2013-14Love2011-12Howard2010-11Durant2008-09Howard2008-09Durant4322222111111111111111111
NAMESEASONTMGPPTSREBMPGPPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINASTSTLBLKTOVPF+/-
Anthony DavisAnthony Davis2017-18NOPNOP41916843.547.817.01.82.83.82.016.531.852.00.84.018.814.016.883.61747111589+17
Anthony DavisAnthony Davis2016-17NOPNOP31415342.247.017.73.72.32.31.317.332.054.21.73.055.610.713.082.1126117747+2
Joel EmbiidJoel Embiid2020-21PHIPHI2953337.347.516.54.53.52.53.016.524.567.30.52.520.014.015.093.37597564+26
Anthony DavisAnthony Davis2018-19NOPNOP2943340.947.016.54.02.51.51.018.033.054.51.03.528.610.011.587.08285327+3
Russell WestbrookRussell Westbrook2016-17OKCOKC2983337.549.016.59.52.00.03.015.531.050.04.012.033.314.014.596.675194065+20
Karl MaloneKarl Malone1989-90UTAUTA21133538.056.517.52.52.50.02.021.527.079.60.00.013.517.577.17655045
Charles BarkleyCharles Barkley1987-88PHIPHI2933149.046.515.52.53.51.05.014.026.552.80.03.00.018.523.080.498572107
Nikola JokicNikola Jokic2020-21DENDEN1471545.147.015.08.00.01.07.020.031.064.52.06.033.35.06.083.34580173+3
James HardenJames Harden2019-20HOUHOU1451735.545.017.09.03.00.06.013.021.061.97.014.050.012.014.085.73593062+11
Giannis AntetokounmpoGiannis Antetokounmpo2018-19MILMIL1521636.252.016.07.02.01.01.015.026.057.73.08.037.519.021.090.53672111+12
James HardenJames Harden2018-19HOUHOU1611540.061.015.04.05.00.05.017.038.044.75.020.025.022.025.088.04045053+19
Paul GeorgePaul George2018-19OKCOKC1471537.247.015.04.00.01.02.015.027.055.66.013.046.211.014.078.63740122+12
Karl-Anthony TownsKarl-Anthony Towns2017-18MINMIN1561541.456.015.04.00.01.02.019.032.059.46.08.075.012.015.080.04140124+7
Joel EmbiidJoel Embiid2017-18PHIPHI1461534.546.015.07.00.07.02.014.020.070.02.03.066.716.019.084.23470724+19
DeMarcus CousinsDeMarcus Cousins2016-17SACSAC1461532.346.015.05.01.01.08.011.016.068.84.06.066.720.022.090.93251186-6
James HardenJames Harden2016-17HOUHOU1531642.153.016.017.00.00.08.014.026.053.89.016.056.316.018.088.942170082+13
Karl-Anthony TownsKarl-Anthony Towns2016-17MINMIN1471841.547.018.02.01.03.04.015.022.068.20.03.00.017.020.085.04221342+7
Anthony DavisAnthony Davis2015-16NOPNOP1592043.459.020.04.00.01.02.024.034.070.62.02.0100.09.010.090.04340121+17
Russell WestbrookRussell Westbrook2014-15OKCOKC1491542.449.015.010.03.01.04.016.033.048.51.04.025.016.020.080.042103143-13
Pau GasolPau Gasol2014-15CHICHI1461838.646.018.03.01.00.03.017.030.056.70.00.012.013.092.33931033+5
Kevin LoveKevin Love2013-14MINMIN1451943.445.019.06.01.00.04.015.023.065.22.06.033.313.015.086.74361043-2
Dwight HowardDwight Howard2011-12ORLORL1452343.645.023.03.04.02.03.012.021.057.10.00.021.039.053.84434232+12
Kevin DurantKevin Durant2010-11OKCOKC1471849.847.018.02.02.02.02.015.028.053.64.08.050.013.014.092.95022222-3
Dwight HowardDwight Howard2008-09ORLORL1451946.745.019.00.01.08.05.016.023.069.60.00.013.018.072.24701855+17
Kevin DurantKevin Durant2008-09OKCOKC1461545.746.015.04.02.01.02.010.023.043.52.06.033.324.026.092.34642123-7
StatMuse has game-level data for rebounds going back to the 1982-83 season.