LeBron James has the most games with 22+ points, with 996 games.

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most nba games 22 points
Interpreted as:
most NBA regular-season games by a player 22 or more points
JamesMaloneAbdul-JabbarJordanBryantO'NealChamberlainNowitzkiRobertsonDurantWilkinsAnthonyWestIversonEnglishOlajuwonMaloneHayesBaylorHavlicekPettitDantleyBarkleyPierceEwing996995995865822725721706699693691690687641633630628620607585577574570563562
NAMEGPPTSMPGPPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINREBASTSTLBLKTOVPF+/-
LeBron JamesLeBron James99630,02539.230.17.77.41.60.83.611.020.952.51.84.837.16.48.773.939,0037,6307,3641,6327893,5571,869+6080
Karl MaloneKarl Malone99529,15139.029.310.93.61.50.83.110.719.854.10.10.330.77.810.275.938,83510,8893,5611,4478253,1043,167+2406
Kareem Abdul-JabbarKareem Abdul-Jabbar99529,59029.713.012.30.00.00.05.27.272.412,898
Michael JordanMichael Jordan86528,87939.433.46.45.32.50.92.812.624.451.50.61.834.47.69.184.134,0425,5054,5962,1817642,4322,333+1317
Kobe BryantKobe Bryant82225,94639.531.65.84.91.60.53.111.023.247.31.74.836.17.89.384.232,5034,8004,0281,3274232,5772,164+3872
Shaquille O'NealShaquille O'Neal72521,37638.229.512.22.90.72.62.911.719.559.80.00.05.06.111.354.327,7048,8782,0894881,8532,0692,458+3642
Wilt ChamberlainWilt Chamberlain72127,00637.524.415.17.213.453.417,560
Dirk NowitzkiDirk Nowitzki70619,87038.428.18.92.80.91.02.09.919.251.61.73.844.76.77.589.227,0866,2721,9726636911,3781,793+5076
Oscar RobertsonOscar Robertson69921,75431.10.011.09.110.884.70
Kevin DurantKevin Durant69320,83638.030.17.54.31.11.13.210.219.951.42.25.340.77.48.488.526,3675,1932,9667827842,2511,380+3733
Dominique WilkinsDominique Wilkins69121,11738.430.67.52.80.611.423.149.20.87.08.582.726,5025,1641,9434441,380-8
Carmelo AnthonyCarmelo Anthony69020,01037.729.06.73.11.10.52.810.421.248.91.64.039.76.78.182.525,9904,6432,1267883741,9012,062+2567
Jerry WestJerry West68721,28631.011.18.710.682.2
Allen IversonAllen Iverson64120,13642.931.43.96.32.40.23.710.924.145.11.44.134.68.310.479.527,5022,4874,0661,5261052,3671,276+1932
Alex EnglishAlex English63318,62637.429.46.04.612.222.753.80.05.05.984.423,6823,8002,8831,832
Hakeem OlajuwonHakeem Olajuwon63018,10439.328.712.62.91.93.53.211.420.954.80.00.121.35.87.973.624,7767,9141,8081,2262,2062,0432,355+304
Moses MaloneMoses Malone62817,99039.028.614.61.69.918.553.60.08.811.278.724,5239,1821,0071,620
Elvin HayesElvin Hayes62017,97829.011.70.05.68.169.1
Elgin BaylorElgin Baylor60719,38831.912.07.99.979.0
John HavlicekJohn Havlicek58516,19627.711.05.76.982.7
Bob PettitBob Pettit57717,49630.310.78.911.577.2
Adrian DantleyAdrian Dantley57417,69330.810.90.09.010.883.5
Charles BarkleyCharles Barkley57016,30940.028.612.84.21.80.93.410.117.358.30.72.330.57.710.374.922,7797,3022,3701,0325311,9301,811+268
Paul PiercePaul Pierce56315,83938.828.16.73.91.60.63.09.118.649.12.25.243.17.69.381.821,8583,7582,2188883451,7081,670+2454
Patrick EwingPatrick Ewing56216,12738.928.711.42.21.12.93.311.220.754.40.00.121.16.28.176.121,8706,3961,2286181,6371,8342,044+405