LeBron James has the most games with 25+ points and 5+ assists, with 704 games.

who has the most career games with 25 points 5 assists
Interpreted as:
Who has the most career regular-season games with 25 or more points 5 or more assists?
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JamesJordanHardenIversonWestbrookBryantCurryWadeLillardDurantBirdMaloneDrexlerThomasMarburyPaulMcGradyPaytonEnglishJohnsonIrvingBarkley704428410385359348286278273264260247221210204201199196195188171171
NAMEGPPTSASTMPGPPGRPGAPGSPGBPGTPGFGMFGAFG%3PM3PA3P%FTMFTAFT%MINREBSTLBLKTOVPF+/-
LeBron JamesLeBron James70422,2565,67639.931.67.98.11.70.83.611.521.653.31.95.137.66.69.074.228,0795,5441,1815692,5461,352+4090
Michael JordanMichael Jordan42814,8003,06840.434.66.87.22.71.02.912.924.951.80.61.832.58.29.685.617,2972,9291,1684071,2551,241+364
James HardenJames Harden41013,9383,64337.934.06.78.91.80.74.69.921.047.14.09.939.910.211.886.715,5352,7367502771,8871,108+2796
Allen IversonAllen Iverson38512,7402,94043.533.14.07.62.50.23.811.324.745.91.54.236.28.911.180.416,7521,542967651,470771+1491
Russell WestbrookRussell Westbrook35911,4893,31137.432.08.39.21.90.34.511.323.348.61.74.735.47.69.481.213,4292,9676651121,613975+1612
Kobe BryantKobe Bryant34811,2122,36840.832.26.46.81.60.63.311.323.448.01.84.837.07.99.484.414,1902,2115641981,145915+2055
Stephen CurryStephen Curry2869,2342,21436.732.35.17.71.80.33.311.021.052.15.311.048.45.05.591.510,4971,46951175955670+2891
Dwyane WadeDwyane Wade2788,7382,16039.331.45.57.81.91.23.611.121.053.00.72.233.18.510.679.910,9251,5185273281,002685+1890
Damian LillardDamian Lillard2738,8342,09737.732.44.47.71.00.32.910.421.249.14.39.843.57.27.990.810,2881,20727589793536+1510
Kevin DurantKevin Durant2648,3381,73838.631.67.96.61.11.23.310.820.552.62.45.842.17.58.589.010,2022,095300325883557+1980
Larry BirdLarry Bird2608,3812,01941.232.210.07.812.622.954.91.32.944.75.86.391.410,7022,599629
Karl MaloneKarl Malone2477,5891,49939.930.711.06.11.50.92.911.520.456.00.10.234.47.710.176.89,8472,709361213717767+1174
Clyde DrexlerClyde Drexler2216,6481,65539.330.17.37.52.60.72.911.521.054.90.92.435.76.17.779.58,6931,618574151649670+133
Isiah ThomasIsiah Thomas2106,2282,11940.229.74.210.111.421.752.30.76.27.978.88,451879713
Stephon MarburyStephon Marbury2046,2881,73942.030.83.58.51.50.13.110.921.051.62.15.043.07.08.581.78,56071429728640531+207
Chris PaulChris Paul2015,8682,01137.829.24.910.02.50.22.510.318.555.92.24.647.86.37.189.17,59598949641508502+1376
Tracy McGradyTracy McGrady1996,5031,38841.432.76.97.01.70.92.911.825.047.12.25.738.86.98.977.68,2301,379333182582389+1433
Gary PaytonGary Payton1965,6871,72041.329.05.08.82.20.32.511.221.053.22.04.741.84.76.176.98,10197643051488480+1096
Alex EnglishAlex English1956,1931,29538.431.85.36.62.913.324.354.80.05.16.183.97,4801,039575557
Magic JohnsonMagic Johnson1885,5262,23539.629.47.411.910.118.056.00.71.737.88.69.987.47,4401,382420
Kyrie IrvingKyrie Irving1715,2841,25936.530.94.17.41.50.42.911.221.452.53.27.145.75.25.791.66,24270126176499425+882
Charles BarkleyCharles Barkley1715,1181,11441.729.913.76.52.01.13.810.617.959.20.72.429.88.010.675.47,1232,344348190648538+91
Giannis AntetokounmpoGiannis Antetokounmpo1675,2381,17735.431.412.27.01.41.53.411.419.658.10.93.229.37.710.572.85,9072,038242243570500+1425
Vince CarterVince Carter1655,0741,07041.330.86.56.51.40.92.411.022.349.42.45.444.66.47.783.26,8211,067235154403484+1295
Tim HardawayTim Hardaway1654,8161,68341.829.24.210.22.10.13.210.720.651.92.86.344.15.06.281.26,89268934122523405+375
StatMuse has game-level data for assists going back to the 1982-83 season.