Joe Mixon had his most total touchdowns in a game against the Jaguars on October 4, 2020, with 3 touchdowns.

joe mixon most td in a game
Interpreted as:
Joe Mixon most td in a regular-season game
10/4/2020Mixon12/29/2019Mixon12/16/2018Mixon10/28/2018Mixon9/30/2021Mixon9/12/2021Mixon10/18/2020Mixon12/8/2019Mixon12/1/2019Mixon11/17/2019Mixon10/27/2019Mixon10/20/2019Mixon9/22/2019Mixon12/9/2018Mixon11/18/2018Mixon10/14/2018Mixon10/7/2018Mixon9/9/2018Mixon11/26/2017Mixon11/12/2017Mixon11/5/2017Mixon10/8/2017Mixon3222111111111111111111
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.

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