Kyler Murray had a passer rating of 106.0 with 2,782 yards, 19 touchdowns and 9 interceptions in 10 games with DeAndre Hopkins in 2021.
| NAME | DATE | SEASON | TM | OPP | CMP | ATT | PCT | YDS | AVG | TD | TD% | INT | INT% | SCK | SCKY | RATE | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Kyler Murray | 9/12/2021 | 2021 |  ARI | @ |  TEN | 21 | 32 | 65.6 | 289 | 9.0 | 4 | 12.5 | 1 | 3.1 | 2 | 9 | 121.0 |
| | Kyler Murray | 9/19/2021 | 2021 | ARI | vs |  MIN | 29 | 36 | 80.6 | 400 | 11.1 | 3 | 8.3 | 2 | 5.6 | 3 | 29 | 117.6 |
| | Kyler Murray | 9/26/2021 | 2021 | ARI | @ |  JAX | 28 | 34 | 82.4 | 316 | 9.3 | 0 | 0.0 | 1 | 2.9 | 0 | 0 | 93.1 |
| | Kyler Murray | 10/3/2021 | 2021 | ARI | @ |  LAR | 24 | 32 | 75.0 | 268 | 8.4 | 2 | 6.3 | 0 | 0.0 | 3 | 19 | 120.3 |
| | Kyler Murray | 10/10/2021 | 2021 | ARI | vs |  SF | 22 | 31 | 71.0 | 239 | 7.7 | 1 | 3.2 | 0 | 0.0 | 2 | 29 | 104.1 |
| | Kyler Murray | 10/17/2021 | 2021 | ARI | @ |  CLE | 20 | 30 | 66.7 | 229 | 7.6 | 4 | 13.3 | 0 | 0.0 | 2 | 21 | 129.0 |
| | Kyler Murray | 10/24/2021 | 2021 | ARI | vs |  HOU | 20 | 28 | 71.4 | 261 | 9.3 | 3 | 10.7 | 1 | 3.6 | 4 | 36 | 121.3 |
| | Kyler Murray | 10/28/2021 | 2021 | ARI | vs |  GB | 22 | 33 | 66.7 | 274 | 8.3 | 0 | 0.0 | 2 | 6.1 | 2 | 14 | 67.0 |
| | Kyler Murray | 12/5/2021 | 2021 | ARI | @ |  CHI | 11 | 15 | 73.3 | 123 | 8.2 | 2 | 13.3 | 0 | 0.0 | 1 | 3 | 136.9 |
| | Kyler Murray | 12/13/2021 | 2021 | ARI | vs | LAR | 32 | 49 | 65.3 | 383 | 7.8 | 0 | 0.0 | 2 | 4.1 | 4 | 39 | 72.1 |
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