Alvin Kamara, Gale Sayers and Dub Jones are tied for the most total touchdowns in a game, with 6 touchdowns.

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most 2 td games career
Interpreted as:
most 2 or more td by a player regular-season games career
12/25/2020Kamara12/12/1965Sayers11/25/1951Jones11/21/2021Taylor12/15/2013Charles12/7/2003Portis9/29/2002Alexander10/12/1997Stewart10/14/1990Rice11/22/1981Winslow12/12/1965Hornung12/8/1963Gilchrist12/10/1961Cannon11/26/1961Haynes11/1/1959Brown10/2/1950Shaw11/28/2021Fournette11/21/2021Ekeler9/20/2021Jones11/1/2020Cook10/11/2020Claypool12/15/2019Drake10/27/2019Coleman66655555555555554444444
Results may be incomplete. StatMuse has complete game-level data for touchdowns going back to the 1950 season.