Norm Van Brocklin has the most passing yards in a game with 5+ passing touchdowns, with 554 yards versus the New York Yanks on September 28, 1951.

most 400 yard and 5 touchdown passing games
Interpreted as:
most 400 passing yard and 5 or more touchdown passing regular-season games by a player
9/28/1951Van Brocklin11/18/2012Schaub10/26/2014Roethlisberger1/1/2012Stafford10/6/2013Romo11/1/2015Brees10/28/1962Tittle9/24/1972Namath1/1/2012Flynn11/19/2018Mahomes10/14/1990Montana9/4/1994Marino10/31/2004Manning12/11/1949Lujack9/27/2018Goff12/5/2004McNabb9/5/2013Manning11/19/2000Frerotte9/28/1969Kapp9/21/1986Marino9/17/1989Cunningham12/11/1982Fouts11/10/1991Rypien554527522520506505505496480478476473472468465464462462449448447444442
NAMEDATETMOPPYDSTDGPCMPATTPCTAVGTD%INTINT%SCKSCKYRATE
Norm Van BrocklinNorm Van Brocklin9/28/1951LALAvsNYYNYY55451274165.913.512.224.9128.3
Matt SchaubMatt Schaub11/18/2012HOUHOUvsJAXJAX52751435578.29.69.123.6223121.7
Ben RoethlisbergerBen Roethlisberger10/26/2014PITPITvsINDIND52261404981.610.712.200.000150.6
Matthew StaffordMatthew Stafford1/1/2012DETDET@GBGB52051365961.08.88.523.4218103.8
Tony RomoTony Romo10/6/2013DALDALvsDENDEN50651253669.414.113.912.8436140.0
Drew BreesDrew Brees11/1/2015NONOvsNYGNYG50571395078.010.114.024.000131.7
Y.A. TittleY.A. Tittle10/28/1962NYGNYGvsWASWAS50571273969.212.917.900.0151.4
Joe NamathJoe Namath9/24/1972NYJNYJ@BALBAL49661152853.617.721.413.6123.5
Matt FlynnMatt Flynn1/1/2012GBGBvsDETDET48061314470.510.913.612.3311136.4
Patrick MahomesPatrick Mahomes11/19/2018KCKC@LARLAR47861334671.710.413.036.5330117.6
Joe MontanaJoe Montana10/14/1990SFSF@ATLATL47661324965.39.712.224.1434119.6
Dan MarinoDan Marino9/4/1994MIAMIAvsNENE47351234254.811.311.912.4217124.3
Peyton ManningPeyton Manning10/31/2004INDIND@KCKC47251254456.810.711.412.300122.5
Johnny LujackJohnny Lujack12/11/1949CHBCHBvsCHCCHC46861243961.512.015.437.7110.9
Jared GoffJared Goff9/27/2018LARLARvsMINMIN46551263378.814.115.200.019158.3
Donovan McNabbDonovan McNabb12/5/2004PHIPHIvsGBGB46451324374.410.811.600.0415147.8
Peyton ManningPeyton Manning9/5/2013DENDENvsBALBAL46271274264.311.016.700.0317141.1
Gus FrerotteGus Frerotte11/19/2000DENDENvsSDSD46251365862.18.08.646.931987.0
Joe KappJoe Kapp9/28/1969MINMINvsBALBAL44971284365.110.416.312.3129.7
Dan MarinoDan Marino9/21/1986MIAMIA@NYJNYJ44861305060.09.012.024.0213112.3
Randall CunninghamRandall Cunningham9/17/1989PHIPHI@WASWAS44751344673.99.710.912.2438131.3
Dan FoutsDan Fouts12/11/1982SDSD@SFSF44451334868.89.310.400.000132.6
Mark RypienMark Rypien11/10/1991WASWASvsATLATL44261163151.614.319.400.000136.8
Len DawsonLen Dawson11/1/1964KCKCvsDENDEN43561233860.511.415.837.9106.9
Sid LuckmanSid Luckman11/14/1943CHBCHB@NYGNYG43371213265.613.521.913.1135.4
Results may be incomplete. StatMuse has complete game-level data for passing touchdowns and passing yards going back to the 1950 season.

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