Emmitt Smith had the most games with 50+ rushing yards, with 173 games.

most games 50 yards rushing
Interpreted as:
most regular-season games by a player 50 or more yards rushing
SmithGorePaytonMartinSandersPetersonBettisTomlinsonDorsettHarrisJamesAllenJacksonDickersonFaulkThomasTaylorWattersRigginsLynchDunnGeorgeDillon17315514813512812712712511911911611511411311111010810810610110110099
NAMEGPRUSH YDSATTRUSH AVGRUSH YDS/GRUSH TDREC YDSRECTRGREC AVGREC YDS/GREC TD
Emmitt SmithEmmitt Smith17316,9203,8324.497.81472,784446956.216.110
Frank GoreFrank Gore15513,4732,8274.886.9752,8403384858.418.311
Walter PaytonWalter Payton14815,3923,3334.6104.01003,5373849.223.911
Curtis MartinCurtis Martin13513,1023,0994.297.1832,7053863237.020.010
Barry SandersBarry Sanders12814,4432,7265.3112.8932,3282768.418.29
Adrian PetersonAdrian Peterson12713,4672,6595.1106.01081,9162323238.315.16
Jerome BettisJerome Bettis12712,1662,8894.295.8691,087146717.48.63
LaDainian TomlinsonLaDainian Tomlinson12512,3242,6804.698.61323,5164516227.828.115
Tony DorsettTony Dorsett11911,0252,3274.792.6702,6572919.122.311
Franco HarrisFranco Harris11910,5622,3534.588.8831,5692037.713.25
Edgerrin JamesEdgerrin James11611,4512,7464.298.7752,9723754997.925.610
Marcus AllenMarcus Allen1159,3342,1024.481.2843,1593678.627.514
Steven JacksonSteven Jackson11410,0382,2774.488.1572,9083584848.125.56
Eric DickersonEric Dickerson11312,3522,6534.7109.3821,7382277.715.44
Marshall FaulkMarshall Faulk11110,6102,1764.995.6825,0195204059.745.233
Thurman ThomasThurman Thomas11010,2402,2844.593.1583,223323210.029.320
Fred TaylorFred Taylor10810,6052,1704.998.2602,0072372848.518.66
Ricky WattersRicky Watters1089,5132,2014.388.1673,2413691598.830.010
John RigginsJohn Riggins1069,3732,2284.288.4881,2061508.011.48
Marshawn LynchMarshawn Lynch1019,0031,9584.689.1711,6142012748.016.08
Warrick DunnWarrick Dunn1018,7011,8434.786.1401,8342272668.118.26
Eddie GeorgeEddie George1009,2682,3963.992.7591,6481971958.416.57
Corey DillonCorey Dillon999,7372,0764.798.4681,4061832017.714.26
Ottis AndersonOttis Anderson988,9762,0364.491.6572,2462638.522.94
Matt ForteMatt Forte978,3931,8544.586.5483,1153694808.432.117
StatMuse has game-level data for rushing yards going back to the 1960 season.

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