Answered February 25th, 2020

Since 2017, Derrick Henry has the most games with 100+ rushing yards and 2+ rushing touchdowns, with 6 games.

most games with 100 or more rushing yards and 2 or more rushing tds in the last 4 seasons
Interpreted as:
most games by a player with 100 or more rushing yards and 2 or more rushing tds in the last 4 seasons

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