12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

most interceptions in a football game
Interpreted as:
most defensive interceptions by a player in a football regular-season game

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