25 players are tied for the most interception touchdowns in a game, scoring 2 touchdowns. The first three are Zach Brown on December 30, 2012, Janoris Jenkins on November 25, 2012 and David Bowens on October 24, 2010.

most interceptions return for touchdowns in a regular season or postseason game against peyton manning
Interpreted as:
most interceptions return for touchdowns by a player in a regular season or postseason game against Peyton Manning
12/30/2012Brown11/25/2012Jenkins10/24/2010Bowens1/3/2010Johnson11/18/2007Rolle10/22/2006Barber1/26/2003Smith12/8/2002Glenn1/20/2002Williams11/22/1998Washington12/14/1997Smith10/22/1995Norton12/26/1993Allen10/4/1992Massey9/20/1992Jones10/19/1986Burruss11/4/1984Brown12/16/1983Kozlowski11/27/1983Johnson11/21/1976McCray12/3/1973Anderson12/17/1972Parrish10/1/1972Kearney22222222222222222222222
NAMEDATEGAME TYPETMOPPINT TDTKLASTCOMBSCKSCKYINTINT YDSFFFRFR TD
Zach BrownZach Brown12/30/2012REGTENTENvs. JAX
vs.
21341.082109000
Janoris JenkinsJanoris Jenkins11/25/2012REGSTLSTL@ ARI
@
22020.00275000
David BowensDavid Bowens10/24/2010REGCLECLE@ NO
@
21010.00294000
Derrick JohnsonDerrick Johnson1/3/2010REGKCKC@ DEN
@
25160.002105000
Antrel RolleAntrel Rolle11/18/2007REGARIARI@ CIN
@
23140.003127000
Ronde BarberRonde Barber10/22/2006REGTBTBvs. PHI
vs.
27070.002103100
Dwight SmithDwight Smith1/26/2003PSTTBTBvs. OAK
vs.
25050.00294000
Aaron GlennAaron Glenn12/8/2002REGHOUHOU@ PIT
@
28080.002135000
Aeneas WilliamsAeneas Williams1/20/2002PSTSTLSTLvs. GB
vs.
26170.00261110
Dewayne WashingtonDewayne Washington11/22/1998REGPITPITvs. JAX
vs.
20.021300
Otis SmithOtis Smith12/14/1997REGNYJNYJvs. TB
vs.
20.02960
Ken NortonKen Norton10/22/1995REGSFSF@ STL
@
20.02560
Eric AllenEric Allen12/26/1993REGPHIPHIvs. NO
vs.
20.02580
Robert MasseyRobert Massey10/4/1992REGPHXPHXvs. WAS
vs.
20.02720
Henry JonesHenry Jones9/20/1992REGBUFBUFvs. IND
vs.
20.021050
Lloyd BurrussLloyd Burruss10/19/1986REGKCKCvs. SD
vs.
20.031210
Dave BrownDave Brown11/4/1984REGSEASEAvs. KC
vs.
20.021480
Mike KozlowskiMike Kozlowski12/16/1983REGMIAMIAvs. NYJ
vs.
20.02730
Kenny JohnsonKenny Johnson11/27/1983REGATLATLvs. GB
vs.
20.02570
Prentice McCrayPrentice McCray11/21/1976REGNENE@ NYJ
@
221180
Dick AndersonDick Anderson12/3/1973REGMIAMIAvs. PIT
vs.
241210
Lemar ParrishLemar Parrish12/17/1972REGCINCIN@ HOU
@
23900
Jim KearneyJim Kearney10/1/1972REGKCKC@ DEN
@
22750
Ken HoustonKen Houston12/19/1971REGHOUHOUvs. SD
vs.
22640
Miller FarrMiller Farr12/7/1968REGHOUHOUvs. BUF
vs.
22920
Results may be incomplete. StatMuse has complete game-level data for interception touchdowns going back to the 1950 season.

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