25 players are tied for the most interception touchdowns in a game, scoring 2 touchdowns. The first three are Zach Brown on December 30, 2012, Janoris Jenkins on November 25, 2012 and David Bowens on October 24, 2010.

most interceptions return for touchdowns in a regular season or postseason game against peyton manning
Interpreted as:
most interceptions return for touchdowns by a player in a regular season or postseason game against Peyton Manning

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