Since 1992, Julius Peppers has the most sacks, with 159.5 sacks.

most sacks in nfl since 1992
Interpreted as:
most defensive sacks by a player in NFL since 1992
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PeppersStrahanTaylorSuggsWareAllenAbrahamRandleFreeneyMathisRiceSmithMillerJonesJordanDumervilCarterHoustonWattQuinnWakeDonald159.5141.5139.5139.0138.5136.0133.5127.0125.5123.0122.0122.0115.5107.5107.0105.5104.5102.0102.0101.0100.598.0
NAMEGPSCKTKLASTCOMBSCKYINTINT YDSINT TDFFFRFR TD
Julius PeppersJulius Peppers266159.5557162719959.511293451212
Michael StrahanMichael Strahan216141.5338934314124214151
Jason TaylorJason Taylor233139.54071775848110340296
Terrell SuggsTerrell Suggs244139.06242628869957144239151
DeMarcus WareDeMarcus Ware178138.550515265788334413582
Jared AllenJared Allen187136.0503145648851.5655131191
John AbrahamJohn Abraham192133.5445935381604661
John RandleJohn Randle187127.05115661104111
Dwight FreeneyDwight Freeney218125.529249341953.50004741
Robert MathisRobert Mathis192123.0401129530869.511052173
Simeon RiceSimeon Rice174122.02143825254802580
Bruce SmithBruce Smith186122.08528113200690
Von MillerVon Miller150115.541312754070226812691
Chandler JonesChandler Jones139107.5331142473745.510033101
Cameron JordanCameron Jordan176107.038418957370626113100
Elvis DumervilElvis Dumervil162105.5263103366683.5127023130
Kevin CarterKevin Carter224104.52331333660005140
Justin HoustonJustin Houston149102.039095485605452118141
J.J. WattJ.J. Watt135102.0419128547714.5299226161
Robert QuinnRobert Quinn156101.0277813587170003131
Cameron WakeCameron Wake155100.52828236464311202220
Aaron DonaldAaron Donald12798.0285156441726.50002360
Joey PorterJoey Porter18898.045115260312233122102
Mario WilliamsMario Williams15897.531782399560.50001651
Kevin GreeneKevin Greene12597.53180192
StatMuse has season-level data for sacks going back to the 1982 season.