Fred Dryer has the most safeties in a game, with 2 safeties against the Packers on October 21, 1973.
Interpreted as:
most safeties by a player in a regular-season game| NAME | SFTY | DATE | TM | OPP | TKL | AST | COMB | SCK | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | F. Dryer | 2 | 10/21/1973 |  LA | vs |  GB | 0 | 0 | 0 | 0 | |||||||
| 2 | | D. Ezeiruaku | 1 | 11/17/2025 |  DAL | @ |  LV | 3 | 2 | 5 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3 |  | K. Mack | 1 | 11/9/2025 |  LAC | vs |  PIT | 1 | 2 | 3 | 1.0 | 9 | 0 | 0 | 0 | 1 | 0 | 0 |
| 4 | | D. Payne | 1 | 10/19/2025 |  WAS | @ | DAL | 1 | 4 | 5 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 5 | | D. Barnes | 1 | 10/5/2025 |  DET | @ |  CIN | 5 | 3 | 8 | 1.0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | | K. Merriweather | 1 | 9/28/2025 |  TB | vs |  PHI | 1 | 1 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 7 | | A.J. Epenesa | 1 | 12/29/2024 |  BUF | vs |  NYJ | 4 | 0 | 4 | 1.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | | K. Lassiter | 1 | 12/25/2024 |  HOU | vs |  BAL | 3 | 3 | 6 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 9 | | Z. Harrison | 1 | 12/16/2024 |  ATL | @ | LV | 2 | 2 | 4 | 1.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 10 | | H. Landry III | 1 | 11/24/2024 |  TEN | @ | HOU | 3 | 0 | 3 | 1.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| 11 | | B. Young | 1 | 10/24/2024 |  LAR | vs |  MIN | 1 | 1 | 2 | 1.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 12 | | S. Hubbard | 1 | 10/6/2024 | CIN | vs | BAL | 7 | 2 | 9 | 1.0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13 | | D. Jones | 1 | 9/30/2024 |  SEA | @ | DET | 1 | 1 | 2 | 1.0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| 14 | | A. Wright | 1 | 9/15/2024 |  CLE | @ |  JAX | 2 | 1 | 3 | 1.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 15 | | Z. Allen | 1 | 9/8/2024 |  DEN | @ | SEA | 1 | 1 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 16 | | A. Speed | 1 | 1/6/2024 |  IND | vs | HOU | 1 | 0 | 1 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 17 | | P. O'Connor | 1 | 12/10/2023 | TB | @ | ATL | 1 | 0 | 1 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 18 | | A. Davis | 1 | 12/3/2023 |  NYJ | vs | ATL | 2 | 0 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 19 | | C. Campbell | 1 | 11/5/2023 | ATL | vs | MIN | 4 | 0 | 4 | 1.0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 20 | | S. Williams | 1 | 10/29/2023 | DAL | vs | LAR | 1 | 1 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 21 | | M. Killebrew | 1 | 10/8/2023 | PIT | vs | BAL | 1 | 0 | 1 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 22 | | N. Morrow | 1 | 9/25/2023 | PHI | @ | TB | 2 | 0 | 2 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 23 |  | M. Judon | 1 | 9/24/2023 |  NE | @ | NYJ | 2 | 3 | 5 | 2.0 | 12 | 0 | 0 | 0 | 0 | 0 | 0 |
| 24 | | J. Johnson | 1 | 12/11/2022 | NYJ | @ | BUF | 0 | 0 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 25 | | R. Lopez | 1 | 12/4/2022 | HOU | vs | CLE | 5 | 0 | 5 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Results may be incomplete. StatMuse has complete game-level data for safeties going back to the 1960 season.
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