Between the 2000 and 2020 seasons, Chris Chambers and Chad Johnson were were tied for targeted the most times in a game with exactly 0 receptions, with 10 targets.

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most targets without a reception in 1 game 2000 to 2020
Interpreted as:
most targets without a reception by a player in 1 regular-season game 2000 to 2020
12/17/2006Chambers9/29/2002Johnson12/16/2007Toomer12/14/2003Coles10/12/2003Pinkston12/13/2015Cooper1/2/2011Knox9/15/2019Parker11/17/2013Hill9/23/2012Hill11/9/2008Booker9/14/2008Jenkins9/17/2006Wade11/20/2005Booker9/18/2005Colbert9/30/2001Galloway9/17/2000Pinkston1/3/2021Green12/27/2020Perriman11/27/2016Lockett11/20/2016Kerley11/26/2015Jones12/14/2014Thompkins1010999887777777777666666
StatMuse has game-level data for targets going back to the 1999 season.