Between the 2000 and 2020 seasons, Chris Chambers and Chad Johnson were were tied for targeted the most times in a game with exactly 0 receptions, with 10 targets.

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most targets without a reception in 1 game 2000 to 2020
Interpreted as:
most targets without a reception by a player in 1 regular-season game 2000 to 2020
StatMuse has game-level data for targets going back to the 1999 season.