Darren McFadden had the most total touchdowns in a game in 2010, with 4 touchdowns against the Broncos on October 24, 2010.

most tds by one player in a game in the 2010 nfl season
Interpreted as:
most tds by one player in a regular-season game in the 2010 NFL season
10/24/2010McFadden1/2/2011Mathews12/26/2010Kuhn12/16/2010Jackson12/12/2010Turner12/12/2010McFadden12/5/2010Peterson12/5/2010Lynch11/28/2010Hillis11/28/2010Bowe11/21/2010Johnson11/21/2010Jennings11/15/2010Williams11/14/2010Gronkowski10/31/2010Johnson10/25/2010Bryant10/24/2010Britt10/24/2010Evans9/26/2010Boldin9/19/2010Snelling9/19/2010Best9/19/2010McCoy4333333333333333333333

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