Tom Brady has the most career wins by a quarterback as a starter, with 236 wins.

most wins by a quarterback first 50 starts
Interpreted as:
most regular-season wins by a quarterback first 50 starts
BradyManningFavreBreesRoethlisbergerRiversRodgersRyanManningWilsonSmithFlaccoMcNabbBledsoePalmerMcNairAikmanHasselbeckYoungStaffordCollinsElwayRomo23618618617216113413311711710099989898929187858481817978
NAMEGPWCMPATTPCTYDSAVGYDS/GTDTD%INTINT%SCKSCKYRATE
Tom BradyTom Brady3072367,00310,92864.181,8027.5266.56065.51961.85333,35897.7
Peyton ManningPeyton Manning2651866,1209,37165.371,8717.7271.25395.82512.73021,95396.5
Brett FavreBrett Favre2981866,27010,11262.071,4767.1239.95065.03333.35153,41686.2
Drew BreesDrew Brees2861727,12710,52467.780,1377.6280.25705.42432.34182,97998.7
Ben RoethlisbergerBen Roethlisberger2391615,2128,08464.561,7797.6258.54015.02022.55313,51993.8
Philip RiversPhilip Rivers2401345,2608,10464.963,2927.8263.74205.22082.64612,81695.3
Aaron RodgersAaron Rodgers1981334,4236,78665.252,8107.8266.74286.3911.34763,203104.3
Matt RyanMatt Ryan2131175,0767,74465.557,9247.5271.93624.71642.14242,80294.6
Eli ManningEli Manning2341174,8928,11060.356,9577.0243.43664.52443.04102,86784.1
Russell WilsonRussell Wilson1491002,9104,46065.235,1427.9235.92776.2821.84072,664102.3
Alex SmithAlex Smith167993,1855,09562.534,9226.9209.11953.81052.14202,39186.9
Joe FlaccoJoe Flacco175983,7426,06461.740,9156.7233.82243.71442.43662,62384.0
Donovan McNabbDonovan McNabb161983,1485,32359.137,1107.0230.52344.41162.23982,55386.0
Drew BledsoeDrew Bledsoe193983,8316,70157.244,5156.6230.62513.72063.14663,12677.1
Carson PalmerCarson Palmer181923,9336,28662.646,1317.3254.92944.71842.93402,36488.2
Steve McNairSteve McNair153912,6874,46760.230,7626.9201.11713.81162.62481,52082.8
Troy AikmanTroy Aikman139872,5174,02362.628,6147.1205.91453.61052.62011,30585.0
Matt HasselbeckMatt Hasselbeck160853,1355,18460.535,6726.9223.02064.01492.93522,21782.4
Steve YoungSteve Young114842,2053,32066.427,2088.2238.71986.0802.42541,346101.4
Matthew StaffordMatthew Stafford174814,1176,54562.947,8807.3275.23054.71502.33972,59791.0
Kerry CollinsKerry Collins180813,3666,05755.639,4756.5219.32033.41913.23282,16473.6
John ElwayJohn Elway117792,1633,67558.926,7427.3228.61654.5982.72651,87685.3
Tony RomoTony Romo127782,8104,30465.333,8927.9266.92445.71142.62461,66497.2
Mark BrunellMark Brunell151782,7154,54659.731,6107.0209.31814.01052.33782,31984.5
Andy DaltonAndy Dalton144753,0004,81962.333,9157.0235.52194.51272.63051,95387.5