Maurice Jones-Drew gained the most all-purpose yards in a game in 2006, with 303 yards against the Colts on December 10, 2006.

most yards by one player in a game in the 2006 nfl season
Interpreted as:
most yards by one player in a regular-season game in the 2006 NFL season
12/10/2006Jones-Drew11/19/2006Evans11/12/2006Johnson12/31/2006Jones12/30/2006Barber12/24/2006Jackson12/11/2006Hester9/17/2006Carr12/31/2006Johnson9/24/2006Jones-Drew10/29/2006Tomlinson11/19/2006Gore10/22/2006Rossum10/15/2006Barber11/26/2006Jones-Drew11/12/2006Parker12/7/2006Parker11/26/2006Arrington9/7/2006Welker11/5/2006Jackson10/15/2006Hicks10/22/2006Westbrook11/19/2006Sams303265260259258252246245244244240238235227226225223221220219215214212
NAMEDATETMOPPYDSTDRUSH YDSRUSH TDREC YDSREC TDKR YDSKR TDPR YDSPR TD
Maurice Jones-DrewMaurice Jones-Drew12/10/2006JAXJAXvs. IND
vs.
303316621501091130
Lee EvansLee Evans11/19/2006BUFBUF@ HOU
@
26520026520000
Chad JohnsonChad Johnson11/12/2006CINCINvs. SD
vs.
26020026020000
Adam JonesAdam Jones12/31/2006TENTENvs. NE
vs.
2591000015801011
Tiki BarberTiki Barber12/30/2006NYGNYG@ WAS
@
258323432400000
Steven JacksonSteven Jackson12/24/2006STLSTLvs. WAS
vs.
2522150110210000
Devin HesterDevin Hester12/11/2006CHICHI@ STL
@
246200002252210
Chris CarrChris Carr9/17/2006OAKOAK@ BAL
@
245000002060390
Bethel JohnsonBethel Johnson12/31/2006MINMINvs. STL
vs.
244000190225000
Maurice Jones-DrewMaurice Jones-Drew9/24/2006JAXJAX@ IND
@
24411030321109000
LaDainian TomlinsonLaDainian Tomlinson10/29/2006SDSDvs. STL
vs.
240318325710000
Frank GoreFrank Gore11/19/2006SFSFvs. SEA
vs.
238021202600000
Allen RossumAllen Rossum10/22/2006ATLATLvs. PIT
vs.
235000002200150
Tiki BarberTiki Barber10/15/2006NYGNYG@ ATL
@
227018504200000
Maurice Jones-DrewMaurice Jones-Drew11/26/2006JAXJAX@ BUF
@
2261781470101000
Willie ParkerWillie Parker11/12/2006PITPITvs. NO
vs.
225221321200000
Willie ParkerWillie Parker12/7/2006PITPITvs. CLE
vs.
22312231000000
J.J. ArringtonJ.J. Arrington11/26/2006ARIARI@ MIN
@
22110010220100
Wes WelkerWes Welker9/7/2006MIAMIA@ PIT
@
220000670740790
Steven JacksonSteven Jackson11/5/2006STLSTLvs. KC
vs.
219186113300000
Maurice HicksMaurice Hicks10/15/2006SFSFvs. SD
vs.
215040160195000
Brian WestbrookBrian Westbrook10/22/2006PHIPHI@ TB
@
2141101011310000
B.J. SamsB.J. Sams11/19/2006BALBALvs. ATL
vs.
212000009101210
Eddie DrummondEddie Drummond10/1/2006DETDET@ STL
@
21200000210020
Joseph AddaiJoseph Addai11/26/2006INDINDvs. PHI
vs.
208417143700000

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