O.J. Simpson had the most games with 250+ rushing yards, with 2 games.

nfl most games with 250 rushing yards player
Interpreted as:
NFL most regular-season games with 250 or more rushing yards player
SimpsonHenryTaylorMartinMurrayCharlesHarrisonPetersonLewisAlexanderAndersonDillonPayton2111111111111
NAMEGPRUSH YDSATTRUSH AVGRUSH YDS/GRUSH TDREC YDSRECTRGREC AVGREC YDS/GREC TD
O.J. SimpsonO.J. Simpson2523589.0261.54000.00
Derrick HenryDerrick Henry1250347.4250.020000.00
Jonathan TaylorJonathan Taylor1253308.4253.021121.01.00
Doug MartinDoug Martin12512510.0251.0421455.321.00
DeMarco MurrayDeMarco Murray12532510.1253.010020.00
Jamaal CharlesJamaal Charles12592510.4259.023113.03.00
Jerome HarrisonJerome Harrison1286348.4286.0312236.012.00
Adrian PetersonAdrian Peterson1296309.9296.03191219.019.00
Jamal LewisJamal Lewis1295309.8295.020010.00
Shaun AlexanderShaun Alexander1266357.6266.037117.07.00
Mike AndersonMike Anderson1251376.8251.045115.05.00
Corey DillonCorey Dillon12782212.6278.020000.00
Walter PaytonWalter Payton1275406.9275.01616.06.00
StatMuse has game-level data for rushing yards going back to the 1960 season.

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