Edgerrin James had 219 rushing yards against the Seahawks on October 15, 2000.

players with at least 210 rushing yards in a game since 2000
Interpreted as:
players with at least 210 rushing yards in a regular-season game since 2000
10/15/2000James10/22/2000Dillon11/19/2000Taylor12/3/2000Dillon12/3/2000Anderson12/3/2000Dunn12/24/2000Faulk11/11/2001Alexander9/29/2002Tomlinson12/1/2002Williams12/1/2002Tomlinson12/9/2002Williams12/29/2002Portis9/14/2003Lewis12/7/2003Portis12/28/2003Green12/28/2003Tomlinson11/20/2005Johnson12/17/2005Barber11/12/2006Parker11/19/2006Gore12/7/2006Parker12/30/2006Barber9/16/2007Lewis10/14/2007Peterson219278234216251210220266217228220216228295218218243211220213212223234216224
NAMEDATETMOPPRUSH YDSATTYPCRUSH TDREC YDSRECTRGAVGREC TD
Edgerrin JamesEdgerrin James10/15/2000INDIND@SEASEA219385.839119.00
Corey DillonCorey Dillon10/22/2000CINCINvsDENDEN2782212.620000
Fred TaylorFred Taylor11/19/2000JAXJAX@PITPIT234307.8314374.71
Corey DillonCorey Dillon12/3/2000CINCINvsARIARI216356.210000
Mike AndersonMike Anderson12/3/2000DENDEN@NONO251376.845115.00
Warrick DunnWarrick Dunn12/3/2000TBTBvsDALDAL210229.5211225.50
Marshall FaulkMarshall Faulk12/24/2000STLSTL@NONO220326.9241785.91
Shaun AlexanderShaun Alexander11/11/2001SEASEAvsOAKOAK266357.637117.00
LaDainian TomlinsonLaDainian Tomlinson9/29/2002SDSDvsNENE217278.0220465.00
Ricky WilliamsRicky Williams12/1/2002MIAMIA@BUFBUF228278.427461.80
LaDainian TomlinsonLaDainian Tomlinson12/1/2002SDSDvsDENDEN220375.935111144.60
Ricky WilliamsRicky Williams12/9/2002MIAMIAvsCHICHI216317.020030
Clinton PortisClinton Portis12/29/2002DENDENvsARIARI228249.5218229.00
Jamal LewisJamal Lewis9/14/2003BALBALvsCLECLE295309.820010
Clinton PortisClinton Portis12/7/2003DENDENvsKCKC218229.95362318.00
Ahman GreenAhman Green12/28/2003GBGBvsDENDEN2182010.929129.00
LaDainian TomlinsonLaDainian Tomlinson12/28/2003SDSDvsOAKOAK243317.82178152.10
Larry JohnsonLarry Johnson11/20/2005KCKC@HOUHOU211365.926116.00
Tiki BarberTiki Barber12/17/2005NYGNYGvsKCKC220297.6229555.80
Willie ParkerWillie Parker11/12/2006PITPITvsNONO213229.7212226.00
Frank GoreFrank Gore11/19/2006SFSFvsSEASEA212248.8026446.50
Willie ParkerWillie Parker12/7/2006PITPITvsCLECLE223327.010010
Tiki BarberTiki Barber12/30/2006NYGNYG@WASWAS2342310.2324348.00
Jamal LewisJamal Lewis9/16/2007CLECLEvsCINCIN216278.010010
Adrian PetersonAdrian Peterson10/14/2007MINMIN@CHICHI2242011.239129.00