| NAME | SEASON | TM | GP | REC YDS | REC | TRG | AVG | REC YDS/G | REC TD | RUSH YDS | ATT | YPC | RUSH YDS/G | RUSH TD | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | Austin Ekeler | 2021 |  LAC | 16 | 647 | 70 | 94 | 9.2 | 40.4 | 8 | 911 | 206 | 4.4 | 56.9 | 12 |
 | Cordarrelle Patterson | 2021 |  ATL | 16 | 548 | 52 | 69 | 10.5 | 34.3 | 5 | 618 | 153 | 4.0 | 38.6 | 6 |
 | Najee Harris | 2021 |  PIT | 17 | 467 | 74 | 94 | 6.3 | 27.5 | 3 | 1,200 | 307 | 3.9 | 70.6 | 7 |
 | Leonard Fournette | 2021 |  TB | 14 | 454 | 69 | 84 | 6.6 | 32.4 | 2 | 812 | 180 | 4.5 | 58.0 | 8 |
 | Darrel Williams | 2021 |  KC | 17 | 452 | 47 | 57 | 9.6 | 26.6 | 2 | 558 | 144 | 3.9 | 32.8 | 6 |
 | D'Andre Swift | 2021 |  DET | 13 | 452 | 62 | 78 | 7.3 | 34.8 | 2 | 617 | 151 | 4.1 | 47.5 | 5 |
 | Alvin Kamara | 2021 |  NO | 13 | 439 | 47 | 67 | 9.3 | 33.8 | 5 | 898 | 240 | 3.7 | 69.1 | 4 |
 | Brandon Bolden | 2021 |  NE | 17 | 405 | 41 | 49 | 9.9 | 23.8 | 2 | 226 | 44 | 5.1 | 13.3 | 1 |
| J.D. McKissic | 2021 |  WAS | 11 | 397 | 43 | 53 | 9.2 | 36.1 | 2 | 212 | 48 | 4.4 | 19.3 | 2 |
 | Aaron Jones | 2021 |  GB | 15 | 391 | 52 | 65 | 7.5 | 26.1 | 6 | 799 | 171 | 4.7 | 53.3 | 4 |
 | James Conner | 2021 |  ARI | 15 | 375 | 37 | 39 | 10.1 | 25.0 | 3 | 752 | 202 | 3.7 | 50.1 | 15 |
| Ty Johnson | 2021 |  NYJ | 16 | 372 | 34 | 55 | 10.9 | 23.3 | 2 | 238 | 61 | 3.9 | 14.9 | 2 |
 | Jonathan Taylor | 2021 |  IND | 17 | 360 | 40 | 51 | 9.0 | 21.2 | 2 | 1,811 | 332 | 5.5 | 106.5 | 18 |
 | Josh Jacobs | 2021 |  LV | 15 | 348 | 54 | 64 | 6.4 | 23.2 | 0 | 872 | 217 | 4.0 | 58.1 | 9 |
 | Christian McCaffrey | 2021 |  CAR | 7 | 343 | 37 | 41 | 9.3 | 49.0 | 1 | 442 | 99 | 4.5 | 63.1 | 1 |
 | Tony Pollard | 2021 |  DAL | 15 | 337 | 39 | 46 | 8.6 | 22.5 | 0 | 719 | 130 | 5.5 | 47.9 | 2 |
 | Michael Carter | 2021 | NYJ | 14 | 325 | 36 | 55 | 9.0 | 23.2 | 0 | 639 | 147 | 4.3 | 45.6 | 4 |
 | Javonte Williams | 2021 |  DEN | 17 | 316 | 43 | 53 | 7.3 | 18.6 | 3 | 903 | 203 | 4.4 | 53.1 | 4 |
 | Joe Mixon | 2021 |  CIN | 16 | 314 | 42 | 48 | 7.5 | 19.6 | 3 | 1,205 | 292 | 4.1 | 75.3 | 13 |
 | AJ Dillon | 2021 | GB | 17 | 313 | 34 | 37 | 9.2 | 18.4 | 2 | 803 | 187 | 4.3 | 47.2 | 5 |
 | Chase Edmonds | 2021 | ARI | 12 | 311 | 43 | 53 | 7.2 | 25.9 | 0 | 592 | 116 | 5.1 | 49.3 | 2 |
| Nyheim Hines | 2021 | IND | 17 | 310 | 40 | 57 | 7.8 | 18.2 | 1 | 276 | 56 | 4.9 | 16.2 | 2 |
 | David Montgomery | 2021 |  CHI | 14 | 301 | 42 | 51 | 7.2 | 21.5 | 0 | 849 | 225 | 3.8 | 60.6 | 7 |
| Kyle Juszczyk | 2021 |  SF | 17 | 296 | 30 | 38 | 9.9 | 17.4 | 1 | 22 | 8 | 2.8 | 1.3 | 1 |
 | Antonio Gibson | 2021 | WAS | 16 | 294 | 42 | 52 | 7.0 | 18.4 | 3 | 1,037 | 258 | 4.0 | 64.8 | 7 |
StatMuse has season-level data for receiving yards going back to the 1932 season.