12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

the most interceptions in 1 game
Interpreted as:
the most defensive interceptions by a player in 1 regular-season game
10/24/2010Hall10/7/2001O'Neal12/27/1998Lassiter9/29/1985Cherry9/24/1978Buchanon12/3/1973Anderson11/15/1964Brown10/4/1964Hunt12/16/1962Ply11/26/1961Norton12/4/1960Baker11/20/1960Norton9/18/1960Gonsoulin12/2/2018Adams10/22/2017Byard10/16/2011Coleman11/28/2010Quin11/22/2009Bodden10/4/2009Talib12/21/2008Hall12/9/2007Trufant12/2/2007Tatupu11/18/2007Rolle44444444444443333333333
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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