12 players are tied for the most interceptions in a game, with 4 interceptions. The first three are DeAngelo Hall on October 24, 2010, Deltha O'Neal on October 7, 2001 and Kwamie Lassiter on December 27, 1998.

the most interceptions in 1 game
Interpreted as:
the most defensive interceptions by a player in 1 regular-season game
Results may be incomplete. StatMuse has complete game-level data for interceptions going back to the 1960 season.

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