Peyton Manning has the most passing touchdowns by a quarterback in a Week-1 game, with 7 touchdowns versus the Ravens on September 5, 2013.

what quarterback has the most touchdowns in week 1
Interpreted as:
What quarterback has the most passing touchdowns in week 1?
9/5/2013Manning9/13/2009Brees9/8/2019Jackson9/12/2004Culpepper9/12/1999Aikman8/31/1997O'Donnell9/4/1994Marino9/13/1987DeBerg9/8/1985Malone9/2/1984Marino9/4/1983Dickey9/7/1980Simms9/28/1951Van Brocklin9/13/2020Wilson9/13/2020Rodgers9/8/2019Prescott9/9/2018Fitzpatrick9/9/2018Mahomes9/10/2017Stafford9/7/2017Smith9/11/2016Winston9/11/2016Brees9/11/2016Luck76555555555554444444444
NAMEDATETMOPPTDCMPATTPCTYDSAVGTD%INTINT%SCKSCKYRATE
Peyton ManningPeyton Manning9/5/2013DENDENvs. BAL
vs.
7274264.346211.016.700.0317141.1
Drew BreesDrew Brees9/13/2009NONOvs. DET
vs.
6263476.535810.517.612.900137.0
Lamar JacksonLamar Jackson9/8/2019BALBAL@ MIA
@
5172085.032416.225.000.011158.3
Daunte CulpepperDaunte Culpepper9/12/2004MINMINvs. DAL
vs.
5172373.924210.521.700.020147.1
Troy AikmanTroy Aikman9/12/1999DALDAL@ WAS
@
5284957.13627.410.236.11789.0
Neil O'DonnellNeil O'Donnell8/31/1997NYJNYJ@ SEA
@
5182572.027010.820.000.000146.7
Dan MarinoDan Marino9/4/1994MIAMIAvs. NE
vs.
5234254.847311.311.912.4217124.3
Steve DeBergSteve DeBerg9/13/1987TBTBvs. ATL
vs.
5243470.63339.814.712.900129.0
Mark MaloneMark Malone9/8/1985PITPITvs. IND
vs.
5213070.02879.616.713.300126.0
Dan MarinoDan Marino9/2/1984MIAMIA@ WAS
@
5212875.031111.117.900.000150.4
Lynn DickeyLynn Dickey9/4/1983GBGB@ HOU
@
5273187.133310.716.113.218137.6
Phil SimmsPhil Simms9/7/1980NYGNYG@ STL
@
5163151.62809.016.113.2108.9
Norm Van BrocklinNorm Van Brocklin9/28/1951LALAvs. NYY
vs.
5274165.955413.512.224.9128.3
Russell WilsonRussell Wilson9/13/2020SEASEA@ ATL
@
4313588.63229.211.400.0323143.1
Aaron RodgersAaron Rodgers9/13/2020GBGB@ MIN
@
4324472.73648.39.100.000127.5
Dak PrescottDak Prescott9/8/2019DALDALvs. NYG
vs.
4253278.140512.712.500.000158.3
Ryan FitzpatrickRyan Fitzpatrick9/9/2018TBTB@ NO
@
4212875.041714.914.300.000156.3
Patrick MahomesPatrick Mahomes9/9/2018KCKC@ LAC
@
4152755.62569.514.800.010127.5
Matthew StaffordMatthew Stafford9/10/2017DETDETvs. ARI
vs.
4294170.72927.19.812.417113.1
Alex SmithAlex Smith9/7/2017KCKC@ NE
@
4283580.036810.511.400.0316148.6
Jameis WinstonJameis Winston9/11/2016TBTB@ ATL
@
4233271.92818.812.513.100125.1
Drew BreesDrew Brees9/11/2016NONOvs. OAK
vs.
4284266.742310.19.500.014131.3
Andrew LuckAndrew Luck9/11/2016INDINDvs. DET
vs.
4314766.03858.28.500.0217119.5
Marcus MariotaMarcus Mariota9/13/2015TENTEN@ TB
@
4131586.720913.926.700.0224158.3
Tom BradyTom Brady9/10/2015NENEvs. PIT
vs.
4253278.12889.012.500.027143.8
Results may be incomplete. StatMuse has complete game-level data for passing touchdowns going back to the 1950 season.

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