Adrian Peterson has rushed for the most yards by a running back in a game, with 296 yards against the San Diego Chargers on November 4, 2007.

what rusher in the nfl game the most yards per season
Interpreted as:
What rusher in the NFL regular-season game the most rushing yards per season?
11/4/2007Peterson9/14/2003Lewis12/20/2009Harrison10/22/2000Dillon11/20/1977Payton11/25/1976Simpson11/11/2001Alexander1/3/2010Charles1/3/2021Taylor10/23/2011Murray11/4/2012Martin12/3/2000Anderson1/3/2021Henry9/16/1973Simpson12/5/1971Ellison12/4/1997Dillon12/28/2003Tomlinson12/8/1963Gilchrist12/6/2018Henry11/13/1994Sanders10/31/1993Smith11/19/1961Brown296295286278275273266259253253251251250250247246243243238237237237
NAMEDATETMOPPRUSH YDSATTRUSH AVGRUSH TDREC YDSRECTRGREC AVGREC TD
Adrian PetersonAdrian Peterson11/4/2007MINMINvs. SD
vs.
296309.93191219.00
Jamal LewisJamal Lewis9/14/2003BALBALvs. CLE
vs.
295309.820010
Jerome HarrisonJerome Harrison12/20/2009CLECLE@ KC
@
286348.4312236.00
Corey DillonCorey Dillon10/22/2000CINCINvs. DEN
vs.
2782212.620000
Walter PaytonWalter Payton11/20/1977CHICHIvs. MIN
vs.
275406.91616.00
O.J. SimpsonO.J. Simpson11/25/1976BUFBUF@ DET
@
273299.42000
Shaun AlexanderShaun Alexander11/11/2001SEASEAvs. OAK
vs.
266357.637117.00
Jamaal CharlesJamaal Charles1/3/2010KCKC@ DEN
@
2592510.423113.00
Jonathan TaylorJonathan Taylor1/3/2021INDINDvs. JAX
vs.
253308.421121.00
DeMarco MurrayDeMarco Murray10/23/2011DALDALvs. STL
vs.
2532510.110020
Doug MartinDoug Martin11/4/2012TBTB@ OAK
@
2512510.0421455.30
Mike AndersonMike Anderson12/3/2000DENDEN@ NO
@
251376.845115.00
Derrick HenryDerrick Henry1/3/2021TENTEN@ HOU
@
250347.420000
O.J. SimpsonO.J. Simpson9/16/1973BUFBUF@ NE
@
250298.62000
Willie EllisonWillie Ellison12/5/1971LALAvs. NO
vs.
247269.51000
Corey DillonCorey Dillon12/4/1997CINCINvs. TEN
vs.
246396.3430215.00
LaDainian TomlinsonLaDainian Tomlinson12/28/2003SDSDvs. OAK
vs.
243317.82178152.10
Cookie GilchristCookie Gilchrist12/8/1963BUFBUFvs. NYJ
vs.
243366.85000
Derrick HenryDerrick Henry12/6/2018TENTENvs. JAX
vs.
2381714.040000
Barry SandersBarry Sanders11/13/1994DETDETvs. TB
vs.
237269.1016116.00
Emmitt SmithEmmitt Smith10/31/1993DALDAL@ PHI
@
237307.91000
Jim BrownJim Brown11/19/1961CLECLEvs. PHI
vs.
237347.0452317.30
Jim BrownJim Brown11/24/1957CLECLEvs. LA
vs.
237317.642137.00
Le'Veon BellLe'Veon Bell12/11/2016PITPIT@ BUF
@
236386.23624515.50
Doug MartinDoug Martin11/22/2015TBTB@ PHI
@
235278.700010
Results may be incomplete. StatMuse has complete game-level data for rushing yards going back to the 1960 season.

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